1943-83-5 Usage
Description
2-Chloroethyl isocyanate is an organic compound characterized by its liquid state and the presence of a chloroethyl group attached to an isocyanate functional group. This chemical structure endows it with reactivity and versatility in various chemical reactions and synthesis processes.
Uses
Used in Pharmaceutical Synthesis:
2-Chloroethyl isocyanate is used as a key intermediate in the synthesis of various pharmaceutical compounds for their potential therapeutic applications. Its reactivity allows for the formation of diverse chemical entities with specific biological activities.
Used in the Synthesis of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-l,2,3,5-tetrazin-4(3H)-one:
In the pharmaceutical industry, 2-Chloroethyl isocyanate is used as a reactant for the synthesis of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-l,2,3,5-tetrazin-4(3H)-one, a compound with potential applications in medicinal chemistry.
Used in the Synthesis of 1-(2-chloroethyl)-3-(2-hydroxyethyl) urea:
2-Chloroethyl isocyanate is utilized as a building block in the creation of 1-(2-chloroethyl)-3-(2-hydroxyethyl) urea, which may have applications in the development of new drugs or pharmaceutical agents.
Used in the Synthesis of 3-substituted 1-(2-chloroethyl)-3-β-glycosylureas:
This chemical is employed as a synthetic precursor for 3-substituted 1-(2-chloroethyl)-3-β-glycosylureas, contributing to the development of novel bioactive molecules with potential uses in medicine.
Used in the Synthesis of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU):
2-Chloroethyl isocyanate is used as a crucial component in the synthesis of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), a nitrosourea-class antineoplastic agent used in cancer treatment.
Used in the Synthesis of (2-chloroethyl)-4-acetoxybenzyl ester:
In the chemical industry, 2-Chloroethyl isocyanate is used as a reactant for the synthesis of (2-chloroethyl)-4-acetoxybenzyl ester, which may have applications in various chemical processes or as an intermediate in the production of other compounds.
Synthesis Reference(s)
The Journal of Organic Chemistry, 32, p. 1508, 1967 DOI: 10.1021/jo01280a045
Check Digit Verification of cas no
The CAS Registry Mumber 1943-83-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,9,4 and 3 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1943-83:
(6*1)+(5*9)+(4*4)+(3*3)+(2*8)+(1*3)=95
95 % 10 = 5
So 1943-83-5 is a valid CAS Registry Number.
InChI:InChI=1/C3H4ClNO/c4-1-2-5-3-6/h1-2H2
1943-83-5Relevant articles and documents
Synthetic method of nirudine hydrochloride
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Paragraph 0006; 0016; 0026-0028; 0033; 0035-0038; 0042-0044, (2021/08/25)
The invention belongs to the field of medicine synthesis and discloses a synthetic method of hydrochloride. The synthesis method provided by the invention takes 2 - chloroethylamine as a raw material and is subjected to amine ester exchange. After the condensation reaction and the nitrification reaction, bendamustine hydrochloride is obtained. To the synthesis method of the hydrochloride, the toxicity of the reaction reagent is reduced, the safety of the synthesis process is improved, and the accuracy of the reaction yield calculation is improved. The synthesis method provided by the invention is suitable for synthesis of hydrochloride, and the synthesized hydrochloride is used for preparing hydrochloride for injection.
Studies on novel 2-imidazolidinones and tetrahydropyrimidin-2(1H)-ones as potential TACE inhibitors: Design, synthesis, molecular modeling, and preliminary biological evaluation
DasGupta, Shirshendu,Murumkar, Prashant R.,Giridhar, Rajani,Yadav, Mange Ram
body text, p. 3604 - 3617 (2009/09/30)
Compounds belonging to the class of 2-imidazolidinones and tetrahydropyrimidin-2(1H)-ones were synthesized and evaluated for their TACE inhibitory activity. Most of the compounds showed very good TACE inhibitory activity. Docking study clearly indicates importance of the P1′ group of the inhibitor for the TACE inhibitory activity. This work proves that these two classes of molecules could be used as potential leads for the development of TACE inhibitors.
SYNTHESIS, STRUCTURE, AND ANTITUMOR ACTIVITY OF 5-SUBSTITUTED 5--2,2-DIMETHYL-1,3-DIOXANES
Kon'kov, S. A.,Kraiz, B. O.,Shenberg, N. N.,Gindin, V. A.,Stukov, A. N.,et al.
, p. 2092 - 2097 (2007/10/02)
5-Substituted 5--2,2-dimethyl-1,3-dioxanes were synthesized by the nitrosation of 5-substituted 5--2,2-dimethyl-1,3-dioxanes by sodium nitrite in 50percent aqueous acetic acid or by N2O3 in chloroform.Nitrosation takes place regioselectively, irrespective of the method.