19946-10-2

Basic information

• Product Name: Methyl 2-(5-Methylpyridin-2-yl)acetate
• Synonyms: Methyl 2-(5-Methylpyridin-2-yl)acetate
• CAS NO: 19946-10-2
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.18914
• Mol File: 19946-10-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Methyl 2-(5-Methylpyridin-2-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-(5-Methylpyridin-2-yl)acetate(19946-10-2)
• EPA Substance Registry System: Methyl 2-(5-Methylpyridin-2-yl)acetate(19946-10-2)

Safety Data

• Hazardous Substances Data: 19946-10-2(Hazardous Substances Data)

Upstream product

• 589-93-5 2,5-dimethylpyridine 
• 79-22-1 methyl chloroformate 
• 67-56-1 methanol 
• 848093-05-0 (5-methyl-pyridin-2-yl)-acetic acid hydrochloride 
• 848093-05-0 (5-methylpyridin-2-yl)acetic acid 
• 3510-66-5 2-Bromo-5-methylpyridine 
• 1003-73-2 3-picoline-N-oxide 
• 77086-38-5 ketene t-butyldimethylsilyl methyl acetal 

Relevant articles and documents

Metal-free aminothiation of alkynes: Three-component tandem annulation toward indolizine thiones from 2-alkylpyridines, ynals, and elemental sulfur

A metal-free three-component annulation reaction for the synthesis of indolizine thiones via tandem C-C/C-N/C-S bond formation was developed. Various 2-alkylpyridines with aromatic ynals and elemental sulfur proceeded smoothly under catalyst-free conditions, and the desired products were obtained in moderate to excellent yields.

A One-Pot Sonogashira Coupling and Annulation Reaction: An Efficient Route toward 4 H -Quinolizin-4-ones

An efficient one-pot Sonogashira coupling and annulation reaction affording 4 H -quinolizin-4-ones in moderate to excellent yields is described. A variety of substituted iodoarenes and 2-alkylazaarenes were well tolerated, and especially the unsaturated double and triple bonds were compatible under the standard conditions.

External-Photocatalyst-Free Visible-Light-Mediated Synthesis of Indolizines

A visible-light-mediated synthesis of valuable polycyclic indolizine heterocycles from easily accessed brominated pyridine and enol carbamate derivatives has been developed. This process, which operates at room temperature under irradiation from readily available light sources, does not require the addition of an external photocatalyst. Instead, an investigation into the reaction mechanism indicates that the indolizine products themselves may be in some way involved in mediating and accelerating their own formation. Preliminary studies also show that these simple heterocyclic compounds may be capable of facilitating other visible-light-mediated transformations.