2047-13-4

Basic information

• Product Name: H-ARG-PHE-OH ACETATE SALT
• Synonyms: H-ARG-PHE-OH ACETATE SALT;H-ARG-PHE-OH ACOH;L-ARGINYL-L-PHENYLALANINE ACETATE;ARG-PHE ACETATE SALT;arginylphenylalanine;H-Arg-Phe-OH;Arg-Phe-OH;L-Arg-L-Phe-OH
• CAS NO: 2047-13-4
• Molecular Formula: C₁₅H₂₃N₅O₃
• Molecular Weight: 381.43
• Mol File: 2047-13-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.35 g/cm³
• Refractive Index: 1.622
• Storage Temp.: −20°C
• CAS DataBase Reference: H-ARG-PHE-OH ACETATE SALT(CAS DataBase Reference)
• NIST Chemistry Reference: H-ARG-PHE-OH ACETATE SALT(2047-13-4)
• EPA Substance Registry System: H-ARG-PHE-OH ACETATE SALT(2047-13-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 2047-13-4(Hazardous Substances Data)

Usage

Description

H-ARG-PHE-OH ACETATE SALT, also known as a dipeptide formed from L-arginine and L-phenylalanine residues, is a compound that exhibits vasorelaxant activity. This property makes it a potential candidate for various applications in the pharmaceutical and healthcare industries.

Uses

Used in Pharmaceutical Industry:
H-ARG-PHE-OH ACETATE SALT is used as a vasorelaxant agent for promoting the relaxation of blood vessels. This application is particularly relevant for the treatment of conditions characterized by increased vascular resistance, such as hypertension and certain cardiovascular diseases.
Used in Research and Development:
H-ARG-PHE-OH ACETATE SALT is also utilized in research and development for studying the mechanisms underlying vasorelaxation and the potential therapeutic applications of this compound in various medical conditions. This includes the investigation of its effects on vascular smooth muscle cells, endothelial function, and the overall regulation of blood pressure.

InChI:InChI=1/C15H23N5O3/c16-11(7-4-8-19-15(17)18)13(21)20-12(14(22)23)9-10-5-2-1-3-6-10/h1-3,5-6,11-12H,4,7-9,16H2,(H,20,21)(H,22,23)(H4,17,18,19)

Upstream product

• 106819-64-1 N-(N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl)-L-phenylalanine 
• 13726-76-6 t-butyloxycarbonyl-L-arginine 
• 16874-17-2 L-phenylalanine tert-butyl ester 
• 74-79-3 L-arginine 
• 63-91-2 L-phenylalanine 
• 35661-40-6 N-Fmoc L-Phe 
• 187618-60-6 Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine 
• 1119-34-2 L-arginine hydrochloride 
• 2149-70-4 N-nitro-L-arginine 
• 27169-20-6 (Z)-Arg(NO₂)-Phe-OMe 
• 117343-23-4 N-[N^ω-nitro-N^α-(4-nitro-benzyloxycarbonyl)-L-arginyl]-L-phenylalanine ethyl ester 
• 24127-11-5 Z-Arg(NO₂)-Phe-OEt 
• 2304-98-5 N₅-[imino(nitroamino)methyl]-N₂-[(phenylmethoxy)carbonyl]-L-ornithine 
• 14611-34-8 N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginine 

Downstream Products

• 85313-62-8 Adpoc-L-Phe-D-Leu-L-Arg-L-Phe-NH₂ 
• 85313-58-2 t-Bumeoc-L-Phe-D-Leu-L-Arg-L-Phe-NH₂ 
• 63-91-2 L-phenylalanine 

Relevant articles and documents

Use of an internal reference for the quantitative HPLC-UV analysis of solid-phase reactions: A case study of 2-chlorotrityl chloride resin

Here we evaluated the use of internal reference compounds for the rapid assessment of reactions performed in solid-phase. An internal reference compound (commercially available) was bound to the resin, together with the substrate, and cleaved with the products after completion of the reaction. The peak area of the reference compound in the HPLC-UV chromatograms can be correlated directly with those of other compounds present in the reaction mixture, thereby allowing a quantitative interpretation of the chromatograms with respect to conversion and yield. The usefulness of this method was demonstrated by optimization of a protocol for the synthesis of proline-based tripeptides.

Solid-Phase Synthesis of Arginine-Containing Peptides by Guanidine Attachment to a Sulfonyl Linker

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