21573-29-5

Basic information

• Product Name: 4-(acetylamino)-2-nitrobenzoic acid
• Synonyms: 4-Acetamido-2-nitrobenzoic acid; benzoic acid, 4-(acetylamino)-2-nitro-
• CAS NO: 21573-29-5
• Molecular Formula: C₉H₈N₂O₅
• Molecular Weight: 224.1702
• Mol File: 21573-29-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 488.2°C at 760 mmHg
• Flash Point: 249°C
• Density: 1.526g/cm³
• Vapor Pressure: 2.41E-10mmHg at 25°C
• Refractive Index: 1.656
• CAS DataBase Reference: 4-(acetylamino)-2-nitrobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(acetylamino)-2-nitrobenzoic acid(21573-29-5)
• EPA Substance Registry System: 4-(acetylamino)-2-nitrobenzoic acid(21573-29-5)

Safety Data

• Hazardous Substances Data: 21573-29-5(Hazardous Substances Data)

Usage

Description

4-(acetylamino)-2-nitrobenzoic acid is a chemical compound with the molecular formula C9H8N2O5. It is a derivative of benzoic acid and contains an acetylamino group and a nitro group. 4-(acetylamino)-2-nitrobenzoic acid is commonly used in organic synthesis and pharmaceutical research.

Uses

Used in Pharmaceutical Research:
4-(acetylamino)-2-nitrobenzoic acid is used as a pharmaceutical candidate for its potential anti-inflammatory and analgesic properties. It is a promising candidate for the development of new therapeutic drugs.
Used in Organic Synthesis:
4-(acetylamino)-2-nitrobenzoic acid is used as a key intermediate in the synthesis of various organic compounds.
Used in Corrosion Inhibition:
4-(acetylamino)-2-nitrobenzoic acid is used as a corrosion inhibitor to protect metal surfaces from corrosion.
Used in Dye and Pigment Production:
4-(acetylamino)-2-nitrobenzoic acid is used in the production of dyes and pigments due to its chemical properties.

Upstream product

• 2719-14-4 4-acetylamino-2-nitrotoluene 
• 7487-88-9 magnesium sulfate 
• 119-32-4 4-Methyl-3-nitroanilin 

Downstream Products

• 610-36-6 4-amino-2-nitrobenzoic acid 
• 43134-76-5 1-amino-3-acetylamino-6-carboxy-benzene 
• 99-09-2 3-nitro-aniline 
• 84228-46-6 4-amino-2-nitrobenzoic acid ethyl ester 
• 1606159-07-2 C₁₁H₁₁N₃O₂S 
• 1606159-31-2 C₂₁H₂₂N₄O₃ 

Relevant articles and documents

Functionalization of quinazolin-4-ones part 1: Synthesis of novel 7-substituted-2-thioxo quinazolin-4-ones from 4-substituted-2-aminobenzoic acids and PPh3(SCN)2

4-(Nitro, amino, acetylamino)-2-aminobenzoic acid were allowed to react with PPh3(SCN)2 and gave the crossholding 7-nitro, 7-acetylamino- and 7-amino-2-thioxo quinazolin-4-ones respectively. The nature of the substituent at position 4 of the 2-aminobenzoic acids has significant influence on the outcome of the cyclisation reaction with PPh 3(SCN)2. Similarly, the nature of the substituent at position 7 of the 2-substituted quinazolin-4-ones significantly affected the ease with which alkylation reactions could be performed. The alkylation selectivity of the 7- substiuted-2-thioxo quinazolin-4-ones was found to depend on the nature of the alkyl halide and the nature of the substituent at position 2.

Benzyl-piperidine derivatives

Benzly-piperidine derivatives of formula I and their pharmaceutically acceptable salts are used in the control of psychotic disorders which are caused by damage to the dopamine system, especially schizophrenia. STR1 A is STR2 B is STR3 R 1, R 2 and R 3 are independently hydrogen, amino, nitro, halogen, lower-alkly or lower-alkoxy. R 4, R 5 and R 6 are independently hydrogen, nitro, halogen, lower-alkyl, lower-alkoxy, cyano, trifluoromethyl, amino, lower-alkylamino or di-lower-alkylamino. R 7, R 2 and R 9 are independently hydrogen, amino or nitro.

Retinoid-like compounds

The present invention relates to a compound of formula STR1 or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in which X is --O--CO--, --NH--CO--, --CS--NH--, --CO--O--, --CO--NH--, --COS--, --SCO--, --SCH2 --, --CH2 --CH2 --, --C C--, --CH2 --NH--, --COCH2 --, --NHCS--, --CH2 S--, --CH2 O--, --OCH2 --, --NHCH2 -- or --CR5 =CR6 --; Rm and Rk are independently hydrogen, halogen, C1-6 alkyl, hydroxy, C1-6 alkyloxy or nitro; n is zero or one; R4 is --(CH2)t --Y, C1-6 alkyl, or C3-6 cycloalkyl; R1 is --CO2 Z, C1-6 alkyl, CH2 OH, --CONHRy, or CHO; R2 and R3 are independently hydrogen or C1-6 alkyl; Ra and Rb are independently hydrogen or C1-6 alkyl; but when n is one, Ra and Rb together can form a radical of the formula STR2 Y is naphthyl or phenyl, both radicals can be optionally substituted with one to three same or different C1-6 alkyl or halogen; Z is hydrogen or C1-6 alkyl; R5, R6 and Ry are independently hydrogen or C1-6 alkyl; and t is zero to six.