21911-88-6Relevant articles and documents
Apixaban intermediate and preparation method thereof
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Page/Page column 9-13, (2020/05/01)
The embodiment of the invention discloses an apixaban intermediate and a preparation method thereof. The preparation method comprises the following steps: preparation of an intermediate 2, preparationof an intermediate 3, preparation of an intermediate 4, preparation of an intermediate 5, and preparation of apixaban key intermediate 5, 6-dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidyl) phenyl]-2 (1H)-pyridone. According to the apixaban intermediate 5, 6-dihydro-3-(4-morpholinyl)-1-[4-(2-oxo-1-piperidyl) phenyl]-2 (1H)-pyridone and the preparation method thereof provided by the invention, the operation is simple, the reaction condition is mild, the requirement on equipment is low, scale-up production is easier, the yield is high, and the purity of the product is greater than 99%.
Polymer coated magnetically separable organocatalyst for C[sbnd]N bond formation via aza-Michael addition
Panwar, Vineeta,Ray, Siddharth S.,Jain, Suman L.
, p. 5026 - 5032 (2016/11/02)
A polyacrylamide coated magnetite (PAM@MNP) catalyst was synthesized by following a two step approach involving the reaction of magnetite (Fe3O4) particles with coupling agent 3-(trimethoxysilyl)propyl methacrylate followed by grafting of acrylamide and subsequent polymerization via surface initiated radical polymerization technique. The synthesized organocatalyst was used for a one-pot aza-Michael addition reaction of amines with electron deficient alkenes to give β-amino carbonyls. The magnetic properties of the synthesized organocatalyst provide it a facile recovery by external magnet which eliminates the problems arising during catalyst separation by conventional filtration.
Tetrahydroquinolines by lewis acid-promoted friedel-crafts cyclizations
Bunce, Richard A.,Cain, Nicholas R.,Cooper, John G.
, p. 28 - 43 (2013/03/14)
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