2903-34-6

Basic information

• Product Name: N-(4-CHLOROPHENYL)-P-TOLUENESULFONAMIDE
• Synonyms: n-(4-chlorophenyl)-4-methyl-benzenesulfonamid;N-(4-CHLOROPHENYL)-P-TOLUENESULFONAMIDE;N-(p-chlorophenyl)-p-toluenesulphonamide;N-(4-chlorophenyl)-p-toluenesulfonamide(pract);N-(4-Chlorophenyl)-4-methylbenzenesulfonamide
• CAS NO: 2903-34-6
• Molecular Formula: C₁₃H₁₂ClNO₂S
• Molecular Weight: 281.76
• EINECS: 220-801-0
• Mol File: 2903-34-6.mol
• Article Data: 66

Chemical Properties

• Melting Point: 118-122 °C
• Boiling Point: 416.7°Cat760mmHg
• Flash Point: 205.8°C
• Appearance: /
• Density: 1.362g/cm³
• Vapor Pressure: 3.75E-07mmHg at 25°C
• Refractive Index: 1.627
• CAS DataBase Reference: N-(4-CHLOROPHENYL)-P-TOLUENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-CHLOROPHENYL)-P-TOLUENESULFONAMIDE(2903-34-6)
• EPA Substance Registry System: N-(4-CHLOROPHENYL)-P-TOLUENESULFONAMIDE(2903-34-6)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 2903-34-6(Hazardous Substances Data)

Usage

Chemical Properties

white crystalline powder

InChI:InChI=1/C13H12ClNO2S/c1-10-2-8-13(9-3-10)18(16,17)15-12-6-4-11(14)5-7-12/h2-9,15H,1H3

Upstream product

• 106-47-8 4-chloro-aniline 
• 98-59-9 p-toluenesulfonyl chloride 
• 2866-82-2 N-(4-chlorophenyl)benzamide 
• 32324-06-4 N¹-tosyl-N¹,N²-bis(p-chlorophenyl)acetamidine 
• 32324-06-4 N-(4-Chloro-phenyl)-N-{1-[(E)-4-chloro-phenylimino]-ethyl}-4-methyl-benzenesulfonamide 
• 100-01-6 4-nitro-aniline 
• 97-02-9 2,4-Dinitroanilin 
• 4124-41-8 p-toluenesulfonylanhydride 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 108-90-7 chlorobenzene 
• 1679-18-1 4-Chlorophenylboronic acid 
• 70-55-3 toluene-4-sulfonamide 
• 637-87-6 1-Chloro-4-iodobenzene 
• 106-39-8 bromochlorobenzene 

Downstream Products

• 3968-03-4 N-(4-chloro-2-nitrophenyl)-4-methylbenzenesulfonamide 
• 22604-12-2 N-(4-chlorophenyl)-N,4-dimethylbenzenesulfonamide 
• 36078-72-5 N-(4-benzothiazol-2-yl-benzyl)-4-chloro-aniline 
• 106-47-8 4-chloro-aniline 
• 92253-10-6 4-chloro-N-methyl-2-tosylaniline 
• 932-96-7 N-methyl(p-chloroaniline) 
• 101580-64-7 N,N'-bis-(4-chloro-phenyl)-pentanediyldiamine 
• 37051-70-0 4-methyl-N-(4-oxocyclohexa-2,5-dien-1-ylidene)benzenesulfonamide 
• 1395894-79-7 C₂₃H₂₀ClNO₃S 
• 1395894-80-0 C₂₄H₂₀ClNO₄S 
• 1395894-81-1 C₂₄H₂₂ClNO₃S 
• 1395894-87-7 6-chloro-4-(4-methoxyphenyl)quinoline 
• 1395894-88-8 C₁₇H₁₂ClNO₂ 
• 1395894-89-9 C₁₇H₁₄ClNO 

Relevant articles and documents

An overview on the progress and development on the palladium catalyzed direct cyanation

Generation of the positive CN ion and the corresponding direct cyanation are both extremely important for cyanation of aromatic compounds. Hereby, we would like to report the simultaneous use of the new Pd nano-catalyst as well as the three types of the N-arylsulfonyl cyanamides (A, B and C) as potent reagents for the in situ generation of the positive CN ion for the direct cyanation of phenylboronic acids in acetonitrile at reflux conditions.

Synthesis of magnetic chitosan supported metformin-Cu(II) complex as a recyclable catalyst for N-arylation of primary sulfonamides

The application of chitosan, which has received much attention as a natural polymer and effective support, has many advantages such as biodegradability and biocompatibility. In this study, the immobilization of a copper complex on the magnetic chitosan bearing metformin ligand has been developed through immobilizing structurally defined metformin with long tail of (3-chloropropyl)trimethoxysilane (TMOS). The synthesized Fe3O4-chitosan@metformin-Cu(II) complex (Fe3O4-CS@Met-Cu(II)) was used as an effective, reusable and magnetic catalyst in the N-arylation of different derivatives of primary sulfonamides with arylboronic acids in ethanol. The primary sulfonamides were prepared from the reaction of sulfonyl chlorides with sodium cyanate in water under ultrasonic irradiation. Utilizing a wide variety of substrates in EtOH as a green solvent, high yields of the primary and secondary sulfonamides, easy work-up along with the excellent recovery and reusability of the catalyst, make this process a simple, economic and environmentally benign method. The synthesized Fe3O4-CS@Met-Cu(II) was characterized using various techniques such as XRD (X-ray diffraction), EDS (energy-dispersive X-ray spectroscopy), elemental mapping, TEM (transmission electron microscopy), FESEM (field emission scanning electron microscopy), VSM (vibrating sample magnetometer), ICP-MS (inductively coupled plasma mass spectroscopy), TGA (thermogravimetric analysis) and FT-IR (Fourier-transform infrared spectroscopy) analyses. The catalyst can be recycled and reused 5 times with no considerable loss of catalytic activity.

Preparation method of sulfamide compound

The invention belongs to the technical field of organic chemistry, and particularly relates to a preparation method of a sulfamide compound, wherein the structure of the sulfamide compound synthesizedby the method is characterized and confirmed by H NMR and C NMR. The method comprises the following steps: in an organic solvent, carrying out a reaction on an aryl diazonium salt, a sulfur dioxide solid complex and an aryl nitroso compound in the presence of a reducing agent under a heating condition, wherein the diazonium salt and the sulfur dioxide solid complex act to generate aryl sulfonyl free radicals, and then the aryl nitroso compound is attacked; and reducing the generated hydroxylamine to obtain the sulfamide compound. The preparation method of the compound has the advantages of mild conditions, simplicity, high efficiency, no need of catalysts, no need of pre-synthesis of sulfonyl chloride or sodium sulfonate reagents, wide substrate application range, strong functionalgroup compatibility, convenience in separation and purification, and excellent industrial and medicinal chemical application values.