22261-57-0

Basic information

• Product Name: BIS(2-AMINO-4-METHYLPHENYL) DISULFIDE
• Synonyms: BIS(2-AMINO-4-METHYLPHENYL) DISULFIDE;BenzenaMine, 2,2'-dithiobis[5-Methyl-;6,6'-disulfanediylbis(3-Methylaniline)
• CAS NO: 22261-57-0
• Molecular Formula: C₁₄H₁₆N₂S₂
• Molecular Weight: 276.42024
• Mol File: 22261-57-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BIS(2-AMINO-4-METHYLPHENYL) DISULFIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BIS(2-AMINO-4-METHYLPHENYL) DISULFIDE(22261-57-0)
• EPA Substance Registry System: BIS(2-AMINO-4-METHYLPHENYL) DISULFIDE(22261-57-0)

Safety Data

• Hazardous Substances Data: 22261-57-0(Hazardous Substances Data)

Usage

Description

Bis(2-amino-4-methylphenyl) disulfide, with the molecular formula C14H16N2S2, is a sulfur-containing compound that serves as a crucial vulcanizing agent in the rubber industry. It is also used as an intermediate in the synthesis of pharmaceuticals and dyes. Bis(2-amino-4-methylphenyl) disulfide is recognized for its ability to crosslink rubber molecules, which significantly enhances their strength and durability. Bis(2-amino-4-methylphenyl) disulfide is considered to have low toxicity, making it a relatively safe chemical to handle and use when proper safety protocols are followed.

Uses

Used in Rubber Industry:
Bis(2-amino-4-methylphenyl) disulfide is used as a vulcanizing agent for [improving the strength and durability of rubber products]. Its crosslinking ability between rubber molecules results in enhanced product performance and longevity.
Used in Pharmaceutical Synthesis:
Bis(2-amino-4-methylphenyl) disulfide is used as an intermediate in [the synthesis of various pharmaceuticals] for [its potential role in creating new drug compounds].
Used in Dye Synthesis:
Bis(2-amino-4-methylphenyl) disulfide is used as an intermediate in [the synthesis of dyes] for [its contribution to the development of new dye products].

Upstream product

• 95-26-1 2,5-dimethylbenzothiazole 
• 31183-81-0 2-amino-4-methyl-benzenethiol 
• 95-81-8 2-chloro-5-methylaniline 

Downstream Products

• 158507-16-5 α-<<4-methyl-2-(1H-pyrrol-1-yl)phenyl>thio>phenylacetic acid ethyl ester 
• 158507-21-2 α-<<4-methyl-2-(1H-pyrrol-1-yl)phenyl>thio>phenylacetic acid 
• 158507-26-7 9-Methyl-5-phenyl-6-thia-10b-aza-benzo[e]azulen-4-one 
• 1027034-85-0 4-Methyl-2-pyrrol-1-yl-benzenethiol 
• 158507-35-8 bis(4-methyl-2-N-pyrrolylphenyl) disulfide 
• 21224-21-5 N,N-dimethyl-4-(5-methyl-benzothiazol-2-yl)-aniline 
• 75459-92-6 2-amino-4-methyl-benzenethiol; zinc salt (2:1) 

Relevant articles and documents

Facile net cycloaddition approach to optically active 1,5-benzothiazepines

The 1,5-benzothiazepine moiety is well-known as a versatile pharmacophore, and its derivatives are expected to have antagonism against numerous diseases. Thus, it is desirable to develop a synthetic route that enables facile enantioselective preparation of a wide range of such derivatives. Although the cycloaddition approach could be considered a possible route to these compounds, to date, there has been no precedent of such a protocol. We therefore present the first example of a highly enantioselective net [4 + 3] cycloaddition to afford 1,5-benzothiazepines by utilizing α,β-unsaturated acylammonium intermediates generated by chiral isothiourea catalysts, which undergo two sequential chemoselective nucleophilic attacks by 2-aminothiophenols. This protocol provided cycloadducts in extremely high regioselectivity, with a good-to-excellent stereoselectivity being achieved regardless of the steric and electronic properties of the substrates. This method therefore offers promising synthetic routes for the construction of a library of optically active 1,5-benzothiazepines for assay evaluation.

Anthelmintic quaternary salts. 3. Benzothiazolium salts.

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