95-81-8Relevant articles and documents
Industrial Cunninghamia lanceolata carbon supported FeO(OH) nanoparticles-catalyzed hydrogenation of nitroarenes
Fu, Lihua,Li, Dingzhong,Lu, Hao,Qiu, Renhua,Sun, Tulai,Xing, Chen,Yang, Tianbao
, (2022/01/11)
The development of green and efficient methods for hydrogenation of nitroarenes is still highly demanding in organic synthesis. Herein, we report an industrial Cunninghamia lanceolata carbon supported FeO(OH) nanoparticles process for the synthesis of aryl amines with good yields via hydrogenation of nitroarenes. Nine key anti-cancer drug intermediates were successfully achieved with protocol. And Osimertinib intermediate 4m can be smoothly synthesized at a 2.67 kg-scale with >99.5% HPLC purity. This protocol features cheap carbon source, highly catalytic activity, simple operation, kilogram-scalable and recyclable catalysts (eight times without observable losing activity).
N,S co-doped hierarchically porous carbon materials for efficient metal-free catalysis
Hu, Xiwei,Sun, Xun,Song, Qiang,Zhu, Yangyang,Long, Yu,Dong, Zhengping
, p. 742 - 752 (2020/02/21)
Metal-free carbon catalysts with excellent catalytic performance have drawn much research attention recently. Herein, polymer-derived N,S co-doped carbon catalysts (PDNSC-X) with a hierarchically porous structure were facilely prepared by a cost-effective and convenient strategy via carbonization of a N- and S atom-containing polymer precursor and were subsequently used as efficient metal-free catalysts. The catalytic activity of the as-fabricated PDNSC-800 was greater than those of other reported heteroatom-doped carbon catalysts in catalytic reduction of various nitroarenes. The high catalytic activity of PDNSC-800 was related to the synergistic effects of a high surface area, a hierarchically porous structure, abundant N- and S-containing active sites, and defect formation. In addition, the close relationship between the N species (especially pyrrolic N) and high selectivity in metal-free catalytic synthesis was investigated in the reduction of nitroarenes and selective oxidation of ethylbenzene. This study may provide a new strategy to fabricate specific heteroatom-doped metal-free carbon catalysts for environmentally friendly efficient organic transformation.
A Co2B Mediated NaBH4 Reduction Protocol Applicable to a Selection of Functional Groups in Organic Synthesis
Lundevall, Frida Johanne,Elumalai, Vijayaragavan,Drageset, Audun,Totland, Christian,Bj?rsvik, Hans-René
supporting information, p. 3416 - 3425 (2018/07/29)
A high-yielding and high-rate reduction method that operates with alkenes, alkynes, azides, nitriles, and nitroarenes was developed and optimized. The method makes use of sodium borohydride reduction of CoSO4 under release of hydrogen along with the formation of Co2B as a nanoparticle material. The produced Co2B activates the various functional groups for hydride reduction. The protocol was proven to operate with an assortment of functional groups to provide good to excellent yields. Furthermore, the reduction method was successfully adapted, implemented, and developed for a continuous flow approach using the multi-jet oscillating disk (MJOD) flow reactor platform at atmospheric pressure.