22543-52-8

Basic information

• Product Name: 4,4'-BIS(TRIFLUOROMETHYL)BENZHYDROL
• Synonyms: 4,4'-BIS(TRIFLUOROMETHYL)BENZHYDROL
• CAS NO: 22543-52-8
• Molecular Formula: C₁₅H₁₀F₆O
• Molecular Weight: 320.23
• Mol File: 22543-52-8.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4,4'-BIS(TRIFLUOROMETHYL)BENZHYDROL(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-BIS(TRIFLUOROMETHYL)BENZHYDROL(22543-52-8)
• EPA Substance Registry System: 4,4'-BIS(TRIFLUOROMETHYL)BENZHYDROL(22543-52-8)

Safety Data

• Hazardous Substances Data: 22543-52-8(Hazardous Substances Data)

Usage

General Description

4,4’-Bis(trifluoromethyl)benzhydrol is a chemical compound with the molecular formula C14H10F6O. It is a white crystalline solid that is used as a building block in the synthesis of various organic compounds. This chemical is classified as an aromatic alcohol and is widely used in the pharmaceutical and chemical industries as a reagent for organic synthesis. It has a high melting point and is relatively stable under normal conditions. 4,4’-Bis(trifluoromethyl)benzhydrol possesses unique chemical properties due to the presence of the trifluoromethyl group, making it a valuable component in the production of advanced materials and pharmaceuticals.

Upstream product

• 98-08-8 α,α,α-trifluorotoluene 
• 402-49-3 4-bromomethyltrifluoromethylbenzene 
• 21221-91-0 4,4'-bis(trifluoromethyl)benzophenone 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 2786-01-8 (4-trifluoromethylphenyl)lithium 
• 402-43-7 p-trifluoromethylphenyl bromide 

Downstream Products

• 261924-73-6 4,4'-bis(trifluoromethyl)benzhydryl bromide 
• 1555554-64-7 2-((bis(4-(trifluoromethyl)phenyl)methyl)thio)acetamide 
• 1555555-07-1 2-((bis(4-(trifluoromethyl)phenyl)methyl)sulfinyl)acetamide 
• 194017-65-7 chloro-bis(4-trifluoromethyl-phenyl)methane 
• 508211-46-9 methyl 2-{bis[4-(trifluoromethyl)phenyl)methoxy}-5-nitrobenzoate 
• 110283-80-2 1-{2-[Bis-(4-trifluoromethyl-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid 
• 110283-79-9 1,2,5,6-tetrahydro-1-<2-methoxy>ethyl>-3-pyridinecarboxylic acid 
• 132284-15-2 1,2,5,6-tetrahydro-1-<2-methoxy>ethyl>-3-pyridinecarboxylic acid methyl ester 
• 132284-16-3 1-{2-[Bis-(4-trifluoromethyl-phenyl)-methoxy]-ethyl}-piperidine-3-carboxylic acid ethyl ester 
• 134457-99-1 tetrakis<4-(trifluoromethyl)phenyl>ethylene 
• 21221-91-0 4,4'-bis(trifluoromethyl)benzophenone 
• 132284-14-1 1-<<(2-bromoethoxy)-4-(trifluoromethyl)phenyl>methyl>-4-(trifluoromethyl)benzene 
• 87901-60-8 C₁₅H₉F₆⁽¹⁺⁾ 

Relevant articles and documents

Trivalent Rare-Earth Metal Amide Complexes as Catalysts for the Hydrosilylation of Benzophenone Derivatives with HN(SiHMe2)2 by Amine-Exchange Reaction

The rare-earth metal complexes Ln(L1)[N(SiHMe2)2](thf) (Ln=La, Ce, Y; L1=N,N′′-bis(pentafluorophenyl)diethylenetriamine dianion) were synthesized by treating Ln[N(SiHMe2)2]3(thf)2 with L1H2. The lanthanum and cerium derivatives are active catalysts for the hydrosilylation of benzophenone derivatives with HN(SiHMe2)2. An amine-exchange reaction was revealed as a key step of the catalytic cycle, in which Ln?Si?H β-agostic interactions are proposed to promote insertion of the carbonyl moiety into the Si?H bond.

CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the enzyme ceramide galactosyltransferase (CGT), such as, for example, lysosomal storage diseases. Examples of lysosomal storage diseases include, for example, Krabbe disease and Metachromatic Leukodystrophy.

En Route to Stimuli-Responsive Boron-, Nitrogen-, and Sulfur-Doped Polycyclic Aromatic Hydrocarbons

Replacing both meso carbon atoms of the polycyclic aromatic hydrocarbon (PAH) bisanthene by boron atoms creates an efficient blue fluorophore with a strong electron-accepting character. The corresponding meso-B,S-doped bisanthene exhibits a solvent-dependent green-to-orange photoluminescence and undergoes a reversible reduction at E1/2= -2.06V (vs.FcH/FcH+. After oxidation of the sulfur atom, the resulting sulfoxide emits in the blue range of the spectrum, shows only negligible solvatochromism, and a reversible redox transition at E1/2= -1.74 V. Several related B, N- and B, S-containing PAHs have been prepared following the same modular synthetic procedure and are also described herein. In order to systematically compare their optoelectronic properties, all products have been investigated by cyclic voltammetry as well as UV/Vis absorption/emission spectroscopy.