22591-15-7Relevant articles and documents
-
Crotti,P. et al.
, p. 155 - 160 (1973)
-
Direct Asymmetric α-Hydroxylation of Cyclic α-Branched Ketones through Enol Catalysis
Shevchenko, Grigory A.,Pupo, Gabriele,List, Benjamin
supporting information, p. 49 - 53 (2019/01/04)
Enantiopure α-hydroxy carbonyl compounds are common scaffolds in natural products and pharmaceuticals. Although indirect approaches towards their synthesis are known, direct asymmetric methodologies are scarce. Herein, we report the first direct asymmetric α-hydroxylation of α-branched ketones through enol catalysis, enabling a facile access to valuable α-keto tertiary alcohols. The transformation, characterized by the use of nitrosobenzene as the oxidant and a new chiral phosphoric acid as the catalyst, delivers a good scope and excellent enantioselectivities.
Development of a new Lewis base-tolerant chiral LBA and its application to catalytic asymmetric protonation reaction
Cheon, Cheol Hong,Imahori, Tatsushi,Yamamoto, Hisashi
supporting information; experimental part, p. 6980 - 6982 (2010/11/02)
A new Lewis base-tolerant LBA (Lewis Acid Assisted Bronsted Acid) derived from La(OTf)3 and (S)-HOP has been developed as a new chiral Bronsted acid. This acid has been successfully applied as a catalyst to asymmetric protonation reactions of silyl enol ethers of 2-substituted cyclic ketones.