245-10-3

Basic information

• Product Name: 5H-Pyrazino[2,3-b]indole
• Synonyms: 5H-Pyrazino[2,3-b]indole
• CAS NO: 245-10-3
• Molecular Formula: C₁₀H₇N₃
• Molecular Weight: 169.18268
• Mol File: 245-10-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 241-243 °C
• Boiling Point: 380.3±22.0 °C(Predicted)
• Appearance: /
• Density: 1.381±0.06 g/cm3(Predicted)
• PKA: 12.73±0.40(Predicted)
• CAS DataBase Reference: 5H-Pyrazino[2,3-b]indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5H-Pyrazino[2,3-b]indole(245-10-3)
• EPA Substance Registry System: 5H-Pyrazino[2,3-b]indole(245-10-3)

Safety Data

• Hazardous Substances Data: 245-10-3(Hazardous Substances Data)

Usage

Chemical compound

5H-Pyrazino[2,3-b]indole

Structure

Bicyclic structure containing a pyrazine ring fused with an indole ring

Heterocyclic compound

Contains atoms of at least two different elements in the ring structure

Biological activities

Antimicrobial, anti-inflammatory, anticancer

Potential use

Development of new drugs for various medical conditions

Upstream product

• 107-15-3 ethylenediamine 
• 213881-67-5 acetyl-1H-3-indolyle trifluoromethanesulfonate 
• 132993-66-9 2?-bromo-N-acetylindoxyl 
• 518051-07-5 2-(2-azidophenyl)pyrazine 
• 81965-08-4 N-[2-(3-Oxo-3,4,5,6-tetrahydro-pyrazin-2-yl)-phenyl]-acetamide 
• 104014-46-2 1-<2-(Benzylamino)phenyl>ethanon 
• 193959-65-8 N-[2-(3-Oxo-3,4-dihydro-pyrazin-2-yl)-phenyl]-acetamide 
• 7671-90-1 (2-acetylamino-phenyl)-glyoxylic acid ethyl ester 
• 574-17-4 1-acetyl-1H-indole-2,3-dione 
• 16800-68-3 1-acetyl-2,3-dihydro-1H-indol-3-one 
• 518051-06-4 N-[2-(pyrazin-2-yl)phenyl]pivalamide 
• 305811-26-1 2-(2-aminophenyl)pyrazine 
• 146140-95-6 2-pivaloylaminophenyl boronic acid 
• 94350-85-3 5H-piperazino[2,3-b]indole 

Relevant articles and documents

Synthesis of a Masked 2,3-Diaminoindole

A three-step synthesis of masked 2,3-diaminoindole 1 from 2-iodo-3-nitro-1-(phenylsulfonyl)indole (2) has been developed. Treatment of 1 with trifluoroacetic acid generates the unstable 2,3-diamino-1-(phenylsulfonyl)indole (3), which can be trapped with α-dicarbonyl compounds to afford 5H-pyrazino[2,3-b]indoles 7-10.

Synthesis and blue phosphorescent device performances of a new bipolar host material containing pyrazino[2,3-b]indole moiety

A new bipolar host material (CzPhPz) consisting of 5H-pyrazino[2,3-b]indole unit was synthesized and its photophysical properties and device performances were investigated. It showed good electron transport properties with a high triplet energy of 2.83 eV. CzPhPz was effective as the host material for FIrpic-based blue PHOLED with a high quantum efficiency of 15.0%. This journal is

A straightforward synthesis of pyridopyrazino[2,3-b]indoles and indolo [2,3-b]-quinoxaline

1,2-Diamines (ethylenediamine, o-phenylenediamine, 2,3-diamino-pyridine, 3,4-diaminopyridine) were reacted with 1-acetyl-2-bromo-3-indolinone to afford 5H-pyrazino[2,3-b]indoles, indolo[2,3-b]quinoxaline and pyridopyrazino[2,3-b]indole in good yields. Alkylation of the indolic nitrogen atom of these indolic derivatives with 2-chloroethylmorpholine, 2-chloroethyl-dimethylamine and allyl bromide was carried out in order to obtain the corresponding N-alkylated derivatives.