245364-67-4

Basic information

• Product Name: 2-(4-fluoro-benzenesulfonylamino)-3-phenyl-propionic acid tert-butyl ester
• Synonyms: 2-(4-fluoro-benzenesulfonylamino)-3-phenyl-propionic acid tert-butyl ester
• CAS NO: 245364-67-4
• Molecular Weight: 379.452
• Mol File: 245364-67-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-fluoro-benzenesulfonylamino)-3-phenyl-propionic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluoro-benzenesulfonylamino)-3-phenyl-propionic acid tert-butyl ester(245364-67-4)
• EPA Substance Registry System: 2-(4-fluoro-benzenesulfonylamino)-3-phenyl-propionic acid tert-butyl ester(245364-67-4)

Safety Data

• Hazardous Substances Data: 245364-67-4(Hazardous Substances Data)

Upstream product

• 63-91-2 L-phenylalanine 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 15100-75-1 L-phenylalanine tert-butyl ester hydrochloride 

Downstream Products

• 245364-93-6 2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-3-phenyl-propionic acid tert-butyl ester 
• 97801-53-1 (S)-2-(4-fluorophenylsulfonamido)-3-phenylpropanoic acid 
• 245365-23-5 N-benzyloxy-2-[(4-fluoro-benzenesulfonyl)-(4-methyl-benzyl)-amino]-3-phenyl-propionamide 
• 245365-20-2 N-benzyloxy-2-[(4-chloro-benzyl)-(4-fluoro-benzenesulfonyl)-amino]-3-phenyl-propionamide 
• 245365-17-7 2-[benzyl-(4-fluoro-benzenesulfonyl)-amino]-N-benzyloxy-3-phenyl-propionamide 
• 245364-96-9 2-[(4-fluoro-benzenesulfonyl)-(4-methyl-benzyl)-amino]-3-phenyl-propionic acid tert-butyl ester 
• 245364-90-3 2-[benzyl-(4-fluoro-benzenesulfonyl)-amino]-3-phenyl-propionic acid tert-butyl ester 

Relevant articles and documents

Small-molecule inhibitors of the TLR3/dsRNA complex

The protein-RNA interface has been regarded as "undruggable" despite its importance in many biological processes. The toll-like receptor 3 (TLR3)/double-stranded RNA (dsRNA) complex provides an exciting target for a number of infectious diseases and cancers. We describe the development of a series of small-molecule probes that were shown to be competitive inhibitors of dsRNA binding to TLR3 with high affinity and specificity. In a multitude of assays, compound 4a was profiled as a potent antagonist to TLR3 signaling and also repressed the expression of downstream signaling pathways mediated by the TLR3/dsRNA complex, including TNF-α and IL-1β.