25116-00-1 Usage
Description
N-(2-cyanophenyl)acetamide is a chemical compound with the molecular formula C10H9N3O. It is an amide derivative of 2-phenylacetic acid and is commonly used in organic synthesis and pharmaceutical research. This white to off-white crystalline solid is relatively stable under normal conditions and has been studied for its potential antimicrobial and anti-inflammatory properties. Its structure and properties make it a valuable component in the development of new drugs and chemical compounds.
Uses
Used in Pharmaceutical Research:
N-(2-cyanophenyl)acetamide is used as a building block for the synthesis of various pharmaceutical compounds, contributing to the development of new drugs and chemical entities.
Used in Organic Synthesis:
In the field of organic synthesis, N-(2-cyanophenyl)acetamide is utilized as a key intermediate, facilitating the creation of complex organic molecules and contributing to advancements in chemical research.
Used in Antimicrobial Applications:
N-(2-cyanophenyl)acetamide is studied for its potential antimicrobial properties, making it a candidate for use in applications that require the inhibition of microbial growth.
Used in Anti-inflammatory Applications:
Due to its potential anti-inflammatory properties, N-(2-cyanophenyl)acetamide may be employed in applications aimed at reducing inflammation and managing inflammatory conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 25116-00-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,1,1 and 6 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 25116-00:
(7*2)+(6*5)+(5*1)+(4*1)+(3*6)+(2*0)+(1*0)=71
71 % 10 = 1
So 25116-00-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H8N2O/c1-7(12)11-9-5-3-2-4-8(9)6-10/h2-5H,1H3,(H,11,12)
25116-00-1Relevant articles and documents
KOtBu-Promoted Transition-Metal-Free Transamidation of Primary and Tertiary Amides with Amines
Ghosh, Tridev,Jana, Snehasish,Dash, Jyotirmayee
supporting information, p. 6690 - 6694 (2019/09/12)
This work discloses transamidation of primary and tertiary amides with a range of aryl, heteroaryl, and aliphatic amines using potassium tert-butoxide. The reaction proceeds at room temperature under transition-metal-free conditions providing secondary amides in high yields. Moreover, reaction of cyclopropyl amine with tertiary amides proceeds with ring-opening to provide a rapid access to enamides.
Pd-Catalyzed tandem reaction of N-(2-cyanoaryl)benzamides with arylboronic acids: synthesis of quinazolines
Zhu, Jianghe,Shao, Yinlin,Hu, Kun,Qi, Linjun,Cheng, Tianxing,Chen, Jiuxi
supporting information, p. 8596 - 8603 (2018/11/27)
The synthesis of 2,4-disubstituted quinazolines by a palladium-catalyzed reaction of arylboronic acids with N-(2-cyanoaryl)benzamides has been developed with moderate to excellent yields. The method shows good functional group tolerance. In particular, ha
Synthesis of 2-methylbenzoxazoles directly from: N -phenylacetamides catalyzed by palladium acetate
Wang, Biying,Jiang, Chengfei,Qian, Jiasheng,Zhang, Shuwei,Jia, Xiaodong,Yuan, Yu
, p. 101 - 107 (2017/12/27)
A method to synthesize 2-methylbenzoxazoles directly from N-phenylacetamides catalyzed by Pd(OAc)2 in the presence of K2S2O8 and TfOH has been developed. The desired products were obtained in moderate to excellent yields. This approach provides a facile procedure to prepare benzoxazoles with available substrates. It is found that TfOH is the key factor for this cyclization reaction. A plausible mechanism of the reaction is proposed according to the control reactions and the literature.
