6484-28-2

Basic information

• Product Name: 2-METHYLQUINAZOLINE-4-THIOL
• Synonyms: 2-Methyl-3H-quinazoline-4-thione
• CAS NO: 6484-28-2
• Molecular Formula: C₉H₈N₂S
• Molecular Weight: 176.24
• Mol File: 6484-28-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 238.1°C at 760 mmHg
• Flash Point: 97.8°C
• Appearance: /
• Vapor Pressure: 0.0665mmHg at 25°C
• CAS DataBase Reference: 2-METHYLQUINAZOLINE-4-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYLQUINAZOLINE-4-THIOL(6484-28-2)
• EPA Substance Registry System: 2-METHYLQUINAZOLINE-4-THIOL(6484-28-2)

Safety Data

• Hazardous Substances Data: 6484-28-2(Hazardous Substances Data)

Usage

Description

2-METHYLQUINAZOLINE-4-THIOL is a sulfur-containing chemical compound with the molecular formula C9H8N2S, belonging to the quinazoline family. It is recognized for its unique chemical properties and potential biological activities, making it a significant compound for research and development in medicinal and agricultural chemistry.

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-METHYLQUINAZOLINE-4-THIOL is used as a building block for the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Used in Antimicrobial Applications:
2-METHYLQUINAZOLINE-4-THIOL is used as an antimicrobial agent, exhibiting potential activity against a range of microorganisms, which can be beneficial in both medical and agricultural settings.
Used in Antitumor Applications:
2-METHYLQUINAZOLINE-4-THIOL is used as an antitumor agent, showing promise in the study of its potential to combat cancer cells, offering a new avenue for cancer treatment research.
Used in Corrosion Inhibition:
2-METHYLQUINAZOLINE-4-THIOL is used as a corrosion inhibitor for metals, indicating its potential to protect metal surfaces from degradation, which can be valuable in various industrial applications.

InChI:InChI=1/C9H8N2S/c1-6-10-8-5-3-2-4-7(8)9(12)11-6/h2-5H,1H3,(H,10,11,12)/p-1

Upstream product

• 1769-24-0 2-methyl-4-quinazolone 
• 108-24-7 acetic anhydride 
• 2454-39-9 2-aminobenzothioamide 
• 1885-29-6 anthranilic acid nitrile 
• 507-09-5 thioacetic acid 
• 25116-00-1 2-acetamidobenzonitrile 
• 118-92-3 anthranilic acid 
• 62-55-5 thioacetamide 
• 6484-24-8 2-methyl-4-chloroquinazoline 
• 507-09-5 tiolacetic acid 
• 33809-77-7 2-acetamidobenzamide 
• 89-52-1 o-acetylamino-benzoic acid 

Downstream Products

• 95616-39-0 α-phenyl-S-(2-methylquinazolin-4-yl)thioglycolic acid 
• 94392-52-6 anhydro-3-hydroxy-5-methyl-2-phenylthiazolo<3,2-c>quinazolin-4-ium hydroxide 
• 76982-21-3 3-(N,N-diethylamino)-5-methylthiazolo<3,2-c>quinazolin-4-ium chloride 
• 96303-91-2 1-(4-Methoxy-phenyl)-2-(2-methyl-quinazolin-4-ylsulfanyl)-ethanone 
• 700-79-8 2-methylquinazoline 
• 85690-51-3 N-(2-aminobenzyl)acetamide 
• 771562-35-7 4-(4-chloro-3-methyl-phenyl)-2-(2-methyl-quinazolin-4-ylsulfanyl)-4-oxo-butyric acid 

Relevant articles and documents

2-Alkyl(aryl)-quinazolin-4(3 H)-thiones, 2-R-(quinazolin-4(3 H)-ylthio)carboxylic acids and amides: Synthesis, molecular docking, antimicrobial and anticancer properties

In this study, a series of novel 2-alkyl(aryl)-quinazolin-4(3H)-thiones, 2-R-(quinazolin-4(3H)-ylthio)carboxylic acids and amides were synthesized and evaluated for antimicrobial and anticancer activities. Their structure was confirmed by elemental analys

Syntheses of Some 4-Anilinoquinazoline Derivatives

Some 4-N-(3′- or 4′-substituted-phenyl)amino-6,7- dimethoxyquinazolines and the corresponding unsubstituted compounds were synthesized from 2-amino-4,5-dimethoxybenzoic acid and the appropriate substituted anilines. Other related quinazolines or their synthetic intermediates were also obtained. A large number of the described quinazolines are new compounds, while the remaining were prepared by a more efficient procedure. The main goal for the synthesis of these compounds comes from the fact that the 4-anilinoquinazoline pharmacophore is an important unit, which is found among the ATP-competitive inhibitors of several protein kinase enzymes.

Studies on quinazolines. Part I. Annelation to the quinazoline ring utilizing amino acid esters

The reaction of quinazoline-4(3H)-thiones 2a-d with amino acid ester hydrochlorides in boiling solvents, under the basic catalysis, afforded the corresponding substitution products (3-6)a-e in low yield. The reaction could be improved by carrying it without a solvent yielding imidazo[1,2-c]- and pyrimido[1,2-c]quinazolines (7-10)a-e. The antibacterial and antifungal activities of the prepared compounds were tested.