254427-95-7

Basic information

• Product Name: ethyl {(2R)-1-[(1S)-1-phenylethyl]piperidin-2-yl}acetate
• Synonyms: ethyl {(2R)-1-[(1S)-1-phenylethyl]piperidin-2-yl}acetate
• CAS NO: 254427-95-7
• Molecular Weight: 275.391
• Mol File: 254427-95-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl {(2R)-1-[(1S)-1-phenylethyl]piperidin-2-yl}acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl {(2R)-1-[(1S)-1-phenylethyl]piperidin-2-yl}acetate(254427-95-7)
• EPA Substance Registry System: ethyl {(2R)-1-[(1S)-1-phenylethyl]piperidin-2-yl}acetate(254427-95-7)

Safety Data

• Hazardous Substances Data: 254427-95-7(Hazardous Substances Data)

Upstream product

• 107408-35-5 ethyl (2E)-7-chlorohept-2-enoate 
• 5259-98-3 5-chloropentan-1-ol 
• 20074-80-0 5-chloro-pentanal 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 98202-45-0 ethyl (2E)-7-iodohept-2-enoate 

Downstream Products

• 3626-67-3 (R)-2-(2,2-dicyclohexylvinyl)piperidine 
• 35193-73-8 (2R)-(+)-2-(2,2-dicyclohexylethyl)piperidine 
• 1000291-99-5 diethyl (4R)-2-methylene-4-{(2R)-1-[(1S)-phenylethyl]piperidin-2-yl}pentanedioate 
• 254428-01-8 ethyl (2R)-3-phenyl-2-{(2R)-1-[(1S)-1-phenylethyl]piperidin-2-yl}propionate 
• 489-54-3 (1R,2R,9S,10S)-7,15-diazatetracyclo[7.7.1.0^2,7.0^10,15]heptadecane-8,16-dione 
• 254428-02-9 (R)-2-[(R)-1-((S)-1-Phenyl-ethyl)-piperidin-2-yl]-pent-4-enoic acid ethyl ester 

Relevant articles and documents

Stereocontrolled synthesis and alkylation of cyclic β-amino esters: Asymmetric synthesis of a (-)-sparteine surrogate

A convenient method for the stereoselective synthesis of cyclic β-amino esters from an iodo αβ-unsaturated ester and α-methylbenzylamine is described. Subsequent enolate generation and alkylation proceeds with complete stereocontrol, with the two stereogenic centres working together. In this way, a functionalised piperidine suitable for alkaloid natural product synthesis was prepared. The usefulness of the methodology is exemplified with the concise synthesis of a (-)-sparteine surrogate. The Royal Society of Chemistry.