35193-73-8 Usage
Description
(-)-2-(2,2-dicyclohexylethyl)piperidine is a piperidine derivative with a unique molecular structure featuring two cyclohexyl groups attached to the piperidine ring. This chiral compound is known for its specific stereochemical properties, making it a versatile asset in both the pharmaceutical and chemical industries.
Uses
Used in Pharmaceutical Industry:
(-)-2-(2,2-dicyclohexylethyl)piperidine is used as a chiral ligand in asymmetric synthesis for the development of new pharmaceutical drugs. Its stereochemistry plays a crucial role in the selectivity and efficacy of synthesized compounds, contributing to the creation of more effective medications.
Used in Organic Synthesis:
In the realm of organic synthesis, (-)-2-(2,2-dicyclohexylethyl)piperidine serves as a valuable building block. Its unique structure allows for the construction of complex organic molecules, facilitating advancements in chemical research and the development of novel compounds.
Used in Anti-inflammatory and Analgesic Applications:
Due to its anti-inflammatory and analgesic effects, (-)-2-(2,2-dicyclohexylethyl)piperidine is a potential candidate for the development of new pharmaceutical drugs targeting pain and inflammation. Its properties could lead to the creation of more effective treatments for various conditions that involve these symptoms.
Check Digit Verification of cas no
The CAS Registry Mumber 35193-73-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,1,9 and 3 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 35193-73:
(7*3)+(6*5)+(5*1)+(4*9)+(3*3)+(2*7)+(1*3)=118
118 % 10 = 8
So 35193-73-8 is a valid CAS Registry Number.
35193-73-8Relevant articles and documents
Asymmetric Synthesis and Absolute Configuration of (+)- and (-)-Perhexiline
Tseng, Chih-Chung,Greig, Iain R.,Harrison, William T. A.,Zanda, Matteo
, p. 73 - 78 (2016)
Racemic perhexiline has been used (or is currently undergoing clinical trials) for the treatment of a variety of cardiovascular disorders. Increasing evidence suggests that the (-)-enantiomer should be used, as opposed to the racemic mixture. Here, we report the first asymmetric synthesis of both enantiomers of perhexiline in high enantiomeric excess and the assignment of their (-)-S/(+)-R absolute stereochemistry by X-ray crystallography.
Influence of [2H]-labelled acetic acid as solvent in the synthesis of [2H]-labelled perhexiline
Schou, Soren Christian
experimental part, p. 31 - 35 (2010/04/24)
Preparation of deuterium-labelled perhexiline from an unsaturated analogue was performed via reduction with deuterium gas and PtO2 in acetic acid. Low incorporation was observed when using acetic acid as solvent (most abundant mass peak was MD0+ ), but when changing the solvent to deuterium-labelled acetic acid, e.g. acetic acid-OD or acetic acid-d4, a higher incorporation was observed (most abundant mass peak was MD8+). Using hydrogen gas instead of deuterium gas withdeuterium-labelled acetic acid, high levels of deuterium incorporation were observed (most abundant mass peak was MD5+). An attempt to reduce a precursor with a fully deuterated pyridine to obtain perhexiline with a higher content of deuterium failed. Copyright
