2633-06-9

Basic information

• Product Name: 3-STYRYL-PYRIDINE
• Synonyms: 3-STYRYL-PYRIDINE;AKOS 90299
• CAS NO: 2633-06-9
• Molecular Formula: C₁₃H₁₁N
• Molecular Weight: 181.23314
• Mol File: 2633-06-9.mol
• Article Data: 88

Chemical Properties

• Melting Point: 80-81 °C
• Boiling Point: 302.7°C at 760 mmHg
• Flash Point: 128.4°C
• Appearance: /
• Density: 1.092g/cm³
• Vapor Pressure: 0.00174mmHg at 25°C
• Refractive Index: 1.666
• PKA: 5.88±0.10(Predicted)
• CAS DataBase Reference: 3-STYRYL-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-STYRYL-PYRIDINE(2633-06-9)
• EPA Substance Registry System: 3-STYRYL-PYRIDINE(2633-06-9)

Safety Data

• Hazardous Substances Data: 2633-06-9(Hazardous Substances Data)

Usage

Description

3-Styryl-pyridine, with the molecular formula C13H11N and a molecular weight of 181.23 g/mol, is a styrylpyridine derivative. It features a pyridine ring with a styryl group attached to the third position, making it a valuable building block in the synthesis of bioactive compounds and pharmaceuticals. This chemical compound has garnered attention for its potential applications in various fields, including anti-inflammatory, anticancer, antimicrobial properties, and as a photosensitizer in photodynamic therapy for cancer, as well as in metal coordination chemistry.

Uses

Used in Pharmaceutical Synthesis:
3-Styryl-pyridine is used as a building block for the synthesis of bioactive compounds and pharmaceuticals, leveraging its unique structure to create new drugs with potential therapeutic benefits.
Used in Anti-inflammatory Applications:
3-Styryl-pyridine is being studied for its potential as an anti-inflammatory agent, which could be utilized in the development of treatments for various inflammatory conditions.
Used in Anticancer Applications:
As a compound with potential anticancer properties, 3-Styryl-pyridine is being researched for its ability to combat cancer cells, possibly leading to the creation of novel cancer therapies.
Used in Antimicrobial Applications:
3-Styryl-pyridine is also being investigated for its antimicrobial properties, which could be harnessed to develop new antibiotics or antifungal agents to combat resistant strains.
Used in Photodynamic Therapy:
3-Styryl-pyridine is being explored as a potential photosensitizer in photodynamic therapy for cancer treatment, where it could be activated by light to destroy cancerous cells.
Used in Metal Coordination Chemistry:
In the field of metal coordination chemistry, 3-Styryl-pyridine is being examined for its role as a ligand, which could lead to advances in the design of metal complexes with specific applications in various industries.

InChI:InChI=1/C13H11N/c1-2-5-12(6-3-1)8-9-13-7-4-10-14-11-13/h1-11H/b9-8+

Upstream product

• 500-22-1 3-pyridinecarboxaldehyde 
• 2959-74-2 benzyldiphenylphosphine oxide 
• 141694-17-9 α-(3-pyridyl)-cinnamic acid 
• 462-08-8 pyridin-3-ylamine 
• 100-42-5 styrene 
• 94089-32-4 C₇H₇N₃O₂ 
• 588-72-7 [(E)-2-bromoethenyl]benzene 
• 89878-14-8 3-Diethylboranylpyridine 
• 79296-92-7 triphenyl-(pyridin-3-yl-methyl)-phosphonium chloride 
• 100-52-7 benzaldehyde 
• 626-55-1 3-Bromopyridine 
• 1198-01-2 Me₃SnCPhCH₂ 
• 588-73-8 (Z)-β-bromostyrene 
• 103-64-0 bromostyrene 

Downstream Products

• 6312-09-0 3-(2-phenylethyl)pyridine 
• 5097-90-5 (Z)-3-styrylpyridine 
• 136423-13-7 3-phenethylpiperidine 
• 91848-84-9 2-methyl-8-(2-phenylethyl)imidazo[1,2-a]pyridine-3-acetonitrile 
• 54768-59-1 2-amino-5-(2-phenylethyl)pyridine 
• 91848-85-0 2-amino-3-(2-phenylethyl)pyridine 
• 85333-07-9 2-Methyl-6-phenethyl-imidazo[1,2-a]pyridine 
• 96428-94-3 2-Methyl-8-(2-phenylethyl)-imidazo(1,2-a)pyridine 

Relevant articles and documents

Di- and tri-nuclear-palladium complexes bearing piperidoimidazolin-2-ylidenes: Synthesis, characterization, and catalytic applications

A series of di- and tri-nuclear Pd(II) complexes with piperidoimidazolin-2-ylidenes anchored to benzene ring via methylene spacers were synthesized. The obtained complexes were fully characterized by IR, 1H NMR, 13C NMR spectroscopy

Determination and application of the excited-state substituent constants of pyridyl and substituted phenyl groups

Thirty six 1-pyridyl-2-arylethenes XCH=CHArY (abbreviated XAEY) were synthesized, in which, X is 2-pyridyl, 3-pyridyl and 4-pyridyl and Y is OMe, Me, H, Br, Cl, F, CF3, and CN. Their ultraviolet absorption spectra were measured in anhydrous ethanol, and their wavelengths of absorption maximum λmax were recorded. Also, the 234 λmax values of 1-substituted phenyl-2-arylethylene compounds (XAEY, where X is substituted phenyl) were collected. The excited-state substituent constants (Formula presented.) of three pyridyl groups and 23 substituted phenyl groups (total of 26) were obtained by means of curve-fitting method. Taking the λmax values of 358 samples of bi-arylethene derivatives as a data set and 126 samples of bi-aryl Schiff bases (including nine compounds synthesized by this work) as another data set, quantitative correlation analyses were performed by employing the obtained (Formula presented.) as a parameter, and good results were obtained for the two data sets. The reliability of the obtained (Formula presented.) values was verified. The results of this paper can provide excited-state substituent constants for the study and application of optical properties of conjugated organic compounds containing aryl groups.

Ruthenium-Catalyzed E-Selective Alkyne Semihydrogenation with Alcohols as Hydrogen Donors

Selective direct ruthenium-catalyzed semihydrogenation of diaryl alkynes to the corresponding E-alkenes has been achieved using alcohols as the hydrogen source. The method employs a simple ruthenium catalyst, does not require external ligands, and affords the desired products in > 99% NMR yield in most cases (up to 93% isolated yield). Best results were obtained using benzyl alcohol as the hydrogen donor, although biorenewable alcohols such as furfuryl alcohol could also be applied. In addition, tandem semihydrogenation-alkylation reactions were demonstrated, with potential applications in the synthesis of resveratrol derivatives.