626-55-1Relevant articles and documents
Synthesis method of 3-bromopyridine
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Paragraph 0017-0024, (2020/05/05)
The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method of 3-bromopyridine. The synthesis method comprises the following steps: (1) dropwise adding bromine into pyridine and 80-95% sulfuric acid at 0 DEG C, and reacting at 130-140 DEG C for 7-8 hours; (2) after the reaction is finished, cooling, pouring into ice water, and regulating the pH value to8 by using 6N sodium hydroxide; and (3) extracting with an organic solvent, layering, drying, filtering, concentrating and distilling. The method has the beneficial effects of high yield, mild reaction conditions, simple reaction steps and simple and easily available raw materials, and is suitable for industrial production.
Base-catalyzed aryl halide isomerization enables the 4-selective substitution of 3-bromopyridines
Bandar, Jeffrey S.,Puleo, Thomas R.
, p. 10517 - 10522 (2020/10/18)
The base-catalyzed isomerization of simple aryl halides is presented and utilized to achieve the 4-selective etherification, hydroxylation and amination of 3-bromopyridines. Mechanistic studies support isomerization of 3-bromopyridines to 4-bromopyridines proceedsviapyridyne intermediates and that 4-substitution selectivity is driven by a facile aromatic substitution reaction. Useful features of a tandem aryl halide isomerization/selective interception approach to aromatic functionalization are demonstrated. Example benefits include the use of readily available and stable 3-bromopyridines in place of less available and stable 4-halogenated congeners and the ability to converge mixtures of 3- and 5-bromopyridines to a single 4-substituted product.
Synthesis method of 3-bromopyridine
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Paragraph 0017-0024, (2019/05/28)
The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method of 3-bromopyridine. The invention includes following steps: (1), dropwise adding bromine into pyridine and sulfuric acid of 80-95% at 0 DEG C, and allowing reaction at 130-140 DEG C for 7-8h; (2), cooling after reaction is finished, pouring into ice water, and using 6N sodium hydroxide to adjustPH to 8; (3), using an organic solvent for extraction, layering, drying, filtering, concentrating, and distilling. The synthesis method has the advantages of being high in yield, mild in reaction condition, simple in reaction step, simple and easy-to-obtain in raw material and suitable for industrial production.