271587-45-2Relevant articles and documents
NON-STEROIDAL SELECTIVE GLUCOCORTICOID RECEPTOR AGONISTIC MODULATORS (SEGRAMs) AND USES THEREOF
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Page/Page column 78, (2019/05/15)
The present invention relates to the two enantiomers of a SElective Glucocorticoid Receptor Agonistic Modulator (SEGRAM) of Formula 1 or a derivative thereof; to a deuterated form of a SEGRAM of Formula 1 or a derivative thereof; and to the two deuterated
Identification of dissociated non-steroidal glucocorticoid receptor agonists
Kuzmich, Daniel,Kirrane, Tom,Proudfoot, John,Bekkali, Younes,Zindell, Renee,Beck, Laura,Nelson, Richard,Shih, Cheng-Kon,Kukulka, Alison J.,Paw, Zofia,Reilly, Patty,Deleon, Rodney,Cardozo, Mario,Nabozny, Gerald,Thomson, David
, p. 5025 - 5031 (2008/02/11)
A new series of ligands for the glucocorticoid receptor (GR) is described. SAR development was guided by docking 3 into the GR active site and optimizing an unsubstituted phenyl ring for key interactions found in the steroid A-ring binding pocket. To iden
Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
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, (2008/06/13)
A compound of Formula (IA) or Formula (IB) wherein R1, R2, R3, R4, R5, R6, R7,and R8 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceu