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609806-82-8

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609806-82-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 609806-82-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,0,9,8,0 and 6 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 609806-82:
(8*6)+(7*0)+(6*9)+(5*8)+(4*0)+(3*6)+(2*8)+(1*2)=178
178 % 10 = 8
So 609806-82-8 is a valid CAS Registry Number.

609806-82-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methylpentan-2-one

1.2 Other means of identification

Product number -
Other names 2-Pentanone,1,1,1-trifluoro-4-(5-fluoro-2-methoxyphenyl)-4-methyl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:609806-82-8 SDS

609806-82-8Relevant articles and documents

Optimization of drug-like properties of nonsteroidal glucocorticoid mimetics and identification of a clinical candidate

Harcken, Christian,Riether, Doris,Liu, Pingrong,Razavi, Hossein,Patel, Usha,Lee, Thomas,Bosanac, Todd,Ward, Yancey,Ralph, Mark,Chen, Zhidong,Souza, Donald,Nelson, Richard M.,Kukulka, Alison,Fadra-Khan, Tazmeen N.,Zuvela-Jelaska, Ljiljana,Patel, Mita,Thomson, David S.,Nabozny, Gerald H.

supporting information, p. 1318 - 1323 (2015/01/09)

A series of nonsteroidal dissociated glucocorticoid receptor agonists was optimized for drug-like properties such as cytochrome P450 inhibition, metabolic stability, aqueous solubility, and hERG ion channel inhibition. This effort culminated in the identification of the clinical candidate compound (R)-39.

Nonsteroidal dissociated glucocorticoid agonists containing azaindoles as steroid A-ring mimetics

Riether, Doris,Harcken, Christian,Razavi, Hossein,Kuzmich, Daniel,Gilmore, Thomas,Bentzien, J?rg,Pack, Edward J.,Souza, Donald,Nelson, Richard M.,Kukulka, Alison,Fadra, Tazmeen N.,Zuvela-Jelaska, Ljiljana,Pelletier, Josephine,Dinallo, Roger,Panzenbeck, Mark,Torcellini, Carol,Nabozny, Gerald H.,Thomson, David S.

experimental part, p. 6681 - 6698 (2010/12/19)

Syntheses and structure-activity relationships (SAR) of nonsteroidal glucocorticoid receptor (GR) agonists are described. These compounds contain azaindole moieties as A-ring mimetics and display various degrees of in vitro dissociation between gene trans

Identification of dissociated non-steroidal glucocorticoid receptor agonists

Kuzmich, Daniel,Kirrane, Tom,Proudfoot, John,Bekkali, Younes,Zindell, Renee,Beck, Laura,Nelson, Richard,Shih, Cheng-Kon,Kukulka, Alison J.,Paw, Zofia,Reilly, Patty,Deleon, Rodney,Cardozo, Mario,Nabozny, Gerald,Thomson, David

, p. 5025 - 5031 (2008/02/11)

A new series of ligands for the glucocorticoid receptor (GR) is described. SAR development was guided by docking 3 into the GR active site and optimizing an unsubstituted phenyl ring for key interactions found in the steroid A-ring binding pocket. To iden

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