2859-29-2

Basic information

• Product Name: 1-methyl-3-phenylquinolin-2(1H)-one
• CAS NO: 2859-29-2
• Molecular Formula: C₁₆H₁₃NO
• Molecular Weight: 235.2805
• Mol File: 2859-29-2.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 369.1°C at 760 mmHg
• Flash Point: 168.7°C
• Density: 1.18g/cm³
• Vapor Pressure: 1.22E-05mmHg at 25°C
• Refractive Index: 1.629
• CAS DataBase Reference: 1-methyl-3-phenylquinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-3-phenylquinolin-2(1H)-one(2859-29-2)
• EPA Substance Registry System: 1-methyl-3-phenylquinolin-2(1H)-one(2859-29-2)

Safety Data

• Hazardous Substances Data: 2859-29-2(Hazardous Substances Data)

Usage

Structure

Quinoline ring with a methyl group at position 1 and a phenyl group at position 3

Classification

Derivative of quinoline, also known as a quinolone

Usage

Organic synthesis, medicinal chemistry

Potential applications

Pharmaceutical industry

Possible properties

Bioactive properties

Role

Building block for the synthesis of other pharmaceutical compounds

Value

Important compound in organic and medicinal chemistry

Upstream product

• 529-23-7 o-aminobenzaldehyde 
• 1256971-44-4 N-methyl-2-phenylacrylamide 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 492-38-6 2-phenylacrylic acid 
• 557-21-1 zinc(II) cyanide 
• 1666-96-2 3-phenylquinoline 
• 606-43-9 1-methyl-2-quinolin-2(1H)-one 
• 101-41-7 benzeneacetic acid methyl ester 
• 1865-29-8 2-phenyl-acrylic acid methyl ester 
• 100-61-8 N-methylaniline 
• 141377-54-0 2-nitro-1-phenylethan-1-ol 
• 100-52-7 benzaldehyde 
• 875-79-6 1,2-dimethylindole 
• 102-96-5 (2-nitroethenyl)benzene 

Relevant articles and documents

Synthesis of quinolinones with palladium-catalyzed oxidative annulation between acrylamides and arynes

An unprecedented palladium-catalyzed oxidative annulation of acrylamides with benzyne precursors has been successfully developed. By using this mild "N-H activation/Heck reaction" method, a wide variety of quinolinones were conveniently prepared in one st

Nickel-Catalyzed Intramolecular Arylcyanation for the Synthesis of 3,3-Disubstituted Oxindoles

A nickel-catalyzed arylcyanation reaction for the synthesis of 3,3-disubstituted oxindoles has been developed. This method features a bench-stable precatalyst system and serves as an economical alternative to the existing palladium-catalyzed arylcyanations described to date. A wide scope of oxindole products were accessible in moderate to good yields, and the rich chemistry of the newly installed nitrile functional group was demonstrated in the synthesis of various oxindole derivatives.

Transition-Metal-Free Direct C-H Arylation of Quinoxalin-2(1H)-ones with Diaryliodonium Salts at Room Temperature

A method of synthesizing 3-arylquinoxalin-2(1H)-ones using diaryliodonium tetrafluoroborates under mild conditions is described. This protocol has a wide substrate scope and enables direct C-H functionalization. The synthetic potential of this coupling was explored using a range of readily accessible diaryliodonium salts and quinoxalin-2(1H)-ones.