637-87-6 Usage
Description
1-Chloro-4-iodobenzene is an organic compound that exists as a white to light yellow crystal powder. It is characterized by the presence of a chlorine atom at the 1st position and an iodine atom at the 4th position on a benzene ring. 1-Chloro-4-iodobenzene is known for its chemical properties that make it a versatile reagent in various synthetic applications.
Uses
1. Used in the Suzuki Reaction:
1-Chloro-4-iodobenzene is used as a reagent in the Suzuki reaction, a widely employed method for the formation of carbon-carbon bonds, particularly in the synthesis of biaryl compounds. Its unique substitution pattern and reactivity make it a valuable component in this cross-coupling process.
2. Used in the Synthesis of Clothiapine (C588550):
1-Chloro-4-iodobenzene is utilized as a key intermediate in the synthesis of Clothiapine, an atypical antipsychotic belonging to the dibenzothiazepine chemical class. Clothiapine has demonstrated efficacy in treating patients with treatment-resistant schizophrenia, making it a significant application of this compound in the pharmaceutical industry.
3. Used in the Chemical Synthesis Industry:
Due to its specific substitution pattern and reactivity, 1-Chloro-4-iodobenzene is used as a building block or intermediate in the synthesis of various organic compounds, particularly those with pharmaceutical, agrochemical, or material science applications. Its versatility in synthetic transformations allows for the creation of a wide range of products.
4. Used in Research and Development:
1-Chloro-4-iodobenzene is also employed in research and development settings, where it serves as a model compound for studying reaction mechanisms, exploring new synthetic routes, and developing innovative applications in various fields, including materials science, pharmaceuticals, and agrochemicals.
Purification Methods
Distil it in a vacuum then recrystallise it from EtOH. [Sugden J Chem Soc 1173 1924, Beilstein 5 H 221, 5 III 579, 5 IV 695.]
Check Digit Verification of cas no
The CAS Registry Mumber 637-87-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,3 and 7 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 637-87:
(5*6)+(4*3)+(3*7)+(2*8)+(1*7)=86
86 % 10 = 6
So 637-87-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H4ClI/c7-5-1-3-6(8)4-2-5/h1-4H
637-87-6Relevant articles and documents
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Masson,Race
, p. 1718,1722 (1937)
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The graphite-catalyzed: ipso -functionalization of arylboronic acids in an aqueous medium: metal-free access to phenols, anilines, nitroarenes, and haloarenes
Badgoti, Ranveer Singh,Dandia, Anshu,Parewa, Vijay,Rathore, Kuldeep S.,Saini, Pratibha,Sharma, Ruchi
, p. 18040 - 18049 (2021/05/29)
An efficient, metal-free, and sustainable strategy has been described for the ipso-functionalization of phenylboronic acids using air as an oxidant in an aqueous medium. A range of carbon materials has been tested as carbocatalysts. To our surprise, graphite was found to be the best catalyst in terms of the turnover frequency. A broad range of valuable substituted aromatic compounds, i.e., phenols, anilines, nitroarenes, and haloarenes, has been prepared via the functionalization of the C-B bond into C-N, C-O, and many other C-X bonds. The vital role of the aromatic π-conjugation system of graphite in this protocol has been established and was observed via numerous analytic techniques. The heterogeneous nature of graphite facilitates the high recyclability of the carbocatalyst. This effective and easy system provides a multipurpose approach for the production of valuable substituted aromatic compounds without using any metals, ligands, bases, or harsh oxidants.
A convenient synthetic approach to a novel class of aryldifluoromethyl pyrimidine derivatives containing strobilurin motif as insecticidal agents
Cai, Zengfei,Cao, Yangyang,Du, Xiaohua,Hao, Shulin,Zhang, Wenliang
supporting information, (2021/10/07)
A series of aryldifluoromethyl pyrimidine compounds containing strobilurin were synthesized through bioelectronic isometric design with azoxystrobin as the lead compound and a convenient approach to aryldifluoromethylpyrimidine intermediates was developed, which features mild reaction conditions and simple operation. The title compounds and aryldifluoromethylpyrimidine intermediates were characterized by NMR and HRMS. Both 7c and 7l of the preliminary screening tests showed 100% inhibition against Mythimna separata at 100 mg/L. At 20 mg/L, the lethal rate of 7l against Mythimna separata can be up to 80%.
