29425-81-8Relevant articles and documents
Application of chiral TADDOL ligand and rare earth metal amide in combined catalysis of asymmetric reaction
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Paragraph 0196-0199, (2020/11/23)
The invention relates to application of chiral TADDOL ligand and rare earth metal amide in combined catalysis of asymmetric epoxidation reaction of chalcone compounds. According to the application, alpha, beta-unsaturated ketone shown in a formula (1) and tert-butyl hydroperoxide react in the presence of organic alkali under the combined catalytic action of a chiral TADDOL ligand shown in a formula (3) and rare earth metal amide in an anhydrous, oxygen-free and protective atmosphere to obtain the chiral epoxy compound shown in the formula (2) after the reaction is completed, wherein R1 is selected from hydrogen, alkyl, halogen, alkoxy, trifluoromethyl, nitro or cyano, R2 is selected from phenyl, substituted phenyl, naphthyl, furyl or thienyl; R3 and R4 are respectively and independently selected from alkyl, phenyl or R3 and R4 and carbon atoms connected with R3 and R4 form naphthenic base; Ar is phenyl, substituted phenyl, biphenyl or naphthyl; the molecular formula of the rare earth metal amide is RE [N (SiMe3) 2] 3. The method has the advantages of wide substrate application range, high yield and high enantioselectivity.
Synthesis and Catalytic Asymmetric Applications of Quinazolinol Ligands
Karakaya, Idris,Karabuga, Semistan,Mart, Mehmet,Altundas, Ramazan,Ulukanli, Sabri
, p. 1719 - 1726 (2016/05/24)
A range of chiral quinazolinol ligands were efficiently synthesized and subsequently investigated for catalytic chiral induction in both the asymmetric phenylation of aryl aldehydes and the asymmetric epoxidation of chalcones. Encouragingly, high enantioselectivities (up to 95%) and yields (up to 98%) were achieved under the optimized reaction conditions.
Preparation of mesoporous zeolite ETS-10 catalysts for high-yield synthesis of α,β-epoxy ketones
Xiang, Mei,Ni, Xiaojun,Yi, Xianfeng,Zheng, Anmin,Wang, Wenchang,He, Mingyang,Xiong, Jing,Liu, Taotao,Ma, Yuli,Zhu, Pengyuan,Zheng, Xiang,Tang, Tiandi
, p. 521 - 525 (2015/03/04)
Developing highly active heterogeneous catalysts for the efficient construction of valuable building blocks is of great importance to synthetic chemistry. For this purpose, a mesoporous zeolite ETS-10 (METS-10) is synthesized by using a mesoscale silane surfactant as a template and applied to achieve highly efficient syntheses of α,β-epoxy ketones by employing simple alkenes and aldehydes as starting materials. The high activity of the METS-10 catalyst is attributed to its unique porous structure and basicity. Electron paramagnetic resonance characterization results and theoretical calculation experimental data reveal that the strong basic sites on METS-10 catalyst can activate the reaction substrate and intermediate. In addition, the mesopores in METS-10 catalyst benefit the mass transfer and further improve the catalytic activity. Mesoporous zeolite ETS-10 is synthesized by using mesoscale silane surfactant as a template and applied to the highly efficient synthesis of α,β-epoxy ketones by employing simple alkenes and aldehydes as starting materials. The high activity of the mesoporous ETS-10 catalyst is attributed to its unique porous structure and basicity.
