295-37-4Relevant articles and documents
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Bounsall,Koprich
, p. 1481,1487 (1970)
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ARENE CONNECTED POLYAMINE MACRORING DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF
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Page/Page column 18-19, (2010/04/24)
Abstract: The present invention relates to arene connected polyamine macrocyclic derivatives represented by general formula I, pharmaceutically acceptable salts or hydrates thereof which have anti-HIV activities, in which the definitions of substituents are as defined in the description; to preparation methods of the compounds of formula I; to pharmaceutical compositions containing the compounds of formula I or their pharmaceutically acceptable salts or hydrates; to the use of the compounds of formula I or their pharmaceutically acceptable salts or hydrates for the preparation of a medicament for the treatment and prevention of HIV-associated diseases.
Cyclohexanedione bisaminals as intermediates for cyclen, homocyclen, and cyclam synthesis
Prokhorov, Anton,Le Bris, Nathalie,Bernard, Helene,Claudon, Geraldine,Handel, Henri
, p. 3271 - 3282 (2007/10/03)
A new easy-to-run route to cyclen, homocyclen, and cyclam is proposed, based on the cyclization with dibromo- or ditosyloxy-derivatives of bisaminal intermediates obtained by condensation of the appropriate linear tetraamine with cyclohexanedione. In the cyclization step, the use of cesium carbonate instead of potassium carbonate as proton trapper caused a remarkable increase of yields. Copyright Taylor & Francis Group, LLC.
Studies on biologically potent tetraazamacrocyclic complexes of bivalent tin
Chaudhary, Ashu,Singh
, p. 615 - 626 (2007/10/03)
Fourteen- to eighteen-membered tetraamide macrocyclic ligands N4L1-N4L4 have been prepared by the condensation of 1,2-diaminoethane or 1,3-diaminopropane with malonic or succinic acid in the presence of condensing reagents dicyclohexylcarbodiimide and 4-dimethylaminopyridine. On reduction, these macrocyclic ligands give a new series of tetraazamacrocycles MacL1-MacL4 which form complexes with tin(II) chloride. The ligands and their complexes were characterized by elemental analyses, molecular weight determinations, infrared and 1H NMR spectral studies. The hexacoordinated state for tin has been confirmed by spectral studies. An octahedral geometry for these complexes has been proposed as the binding sites are the nitrogen atoms of the macrocycles. On the basis of the chemical composition the representation of the complexes as [Sn(MacLn)Cl2] (n = 1-4) has been established. The ligands and their complexes also have been screened for their antifungal and antibacterial activities and the findings have been reported and explained.