3018-48-2Relevant articles and documents
BIO-BASED AROMATIC DIISOCYANATES FOR PREPARATION OF POLYURETHANES
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Page/Page column 9; 10, (2016/07/27)
The present invention provides bio-based aromatic diisocyanate of formula (I). [Formula should be inserted here] wherein X is –OCH3, Y is selected from -H or –OCH3, and m = 0-12. The present invention further provides a method for pr
Pyrrolobenzodiazepines
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, (2008/06/13)
A compound with formula (I) where R10 is a therapeutically removable nitrogen protecting group; R2 and R3 are independently selected from: H, R, OH, OR, =O, =CH—R, =CH2, CH2—CO2R, CH2—CO2H, CH2—SO2R, O—SO2—R, CO2R, COR and CN; R6, R7 and R9 are independently selected from H, R, OH, OR, halo, amino, nitro, Me3Sn; X is S, O or NH; R11 is either H or R; and where there is optionally a double bond between C1 and C2 or C2 and C3; and R8 is selected from H, R, OH, OR, halo, amino, nitro, Me3Sn, or R7 and R8 together form a group —O—(CH2)p—O—, where p is 1 or 2. Such compounds may be used in methods of ADEPT, GDEPT, NPEPT or PDT.
Synthesis of sequence-selective C8-linked pyrrolo[2,1-c][1,4]benzodiazepine DNA interstrand cross-linking agents
Thurston, David E.,Bose, D. Subhas,Thompson, Andrew S.,Howard, Philip W.,Leoni, Alberto,Croker, Stephen J.,Jenkins, Terrence C.,Neidle, Stephen,Hartley, John A.,Hurley, Laurence H.
, p. 8141 - 8147 (2007/10/03)
An efficient convergent synthesis of a homologous series of C8-linked pyrrolobenzodiazepine dimers with remarkable DNA interstrand cross-linking activity and potent in vitro cytotoxicity is reported. The 'amino thioacetal' cyclization procedure was used t
