303176-42-3

Basic information

• Product Name: (2S,αR)-α-(Aminomethyl)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol
• Synonyms: (2S,αR)-α-(Aminomethyl)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol;(2S,αR)-α-(AMinoMethyl)-6-fluoro-chroMan-2-Methanol
• CAS NO: 303176-42-3
• Molecular Formula: C11H14FNO2
• Molecular Weight: 211.23
• Product Categories: Amines;Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Amines, Aromatics, Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 303176-42-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 109-112°C
• Boiling Point: 383.5±37.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.06 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility: Chloroform, Dichloromethane, Methanol
• PKA: 12.68±0.35(Predicted)
• CAS DataBase Reference: (2S,αR)-α-(Aminomethyl)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,αR)-α-(Aminomethyl)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol(303176-42-3)
• EPA Substance Registry System: (2S,αR)-α-(Aminomethyl)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol(303176-42-3)

Safety Data

• Hazardous Substances Data: 303176-42-3(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

(+)-Nebivolol intermediate.

Upstream product

• 303176-41-2 2-azido-1-[6-fluoro-(2S)-3H,4H-2-chromenyl]-(1R)-ethan-1-ol 
• 303176-40-1 (R)-2-[(S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl-4-methylbenzenesulfonate 
• 303176-36-5 ethyl 5-(2-tert-butyldimethylsilyloxy-5-fluoro-phenyl)-2-pentenoate 
• 303176-37-6 5-(2-tert-butyldimethylsilyloxy-5-fluoro-phenyl)-(E)-2-penten-1-ol 
• 303176-35-4 3-(2-tert-butyldimethylsilyloxy-5-fluoro-phenyl)-1-propanol 
• 783332-57-0 3-(2-((tert-butyldimethylsilyl)oxy)-5-fluorophenyl)propanal 
• 303176-34-3 2-alllyl-1-(tert-butyldimethylsilyloxy)-4-fluoro-benzene 
• 303176-38-7 5-(5-fluoro-2-hydroxy-phenyl)-E-2-penten-1-ol 
• 13997-72-3 1-allyl-2-hydroxy-5-fluorobenzene 
• 13990-72-2 1-allyloxy-4-fluorobenzene 
• 303176-39-8 1-[6-fluoro-(2S)-3,4-dihydro-2H-benzopyran-2-yl]-(1R)-1,2-ethylene glycol 
• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 371-41-5 4-Fluorophenol 
• 797054-19-4 (S)-2-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-6-fluoro-2,3-dihydrochromen-4-one 

Downstream Products

• 118457-14-0 (+)-Nebivolol 
• 152520-56-4 d-nebivolol hydrochloride 

Relevant articles and documents

Synthesis of (S,R,R,R)-α,α′-iminobis(methylene)bis(6- fluoro-3H,4H-dihydro-2H-1-benzopyran-2-methanol)

The β1-adrenergic antagonist (S,R,R,R)-α, α′-iminobis(methylene)bis(6-fluoro-3H,4H-dihydro-2H-1-benzopyran-2- methanol) was synthesized from natural chiral pool starting materials through an efficient, convergent synthetic strategy. The cyclization mechanism of the key step was investigated using computer modeling and is discussed. Georg Thieme Verlag Stuttgart.