797054-19-4

Basic information

• Product Name: (1’R,2S)-2-[(1’,2’-O-Isopropylidene)dihydroxyethyl]-6-fluorochroman-4-one
• Synonyms: (1’R,2S)-2-[(1’,2’-O-Isopropylidene)dihydroxyethyl]-6-fluorochroman-4-one;(2S)-2-[(4R)-2,2-DiMethyl-1,3-dioxolan-4-yl]-6-fluoro-2,3-dihydro-4H-1-benzopyran-4-one
• CAS NO: 797054-19-4
• Molecular Formula: C₁₄H₁₅FO₄
• Molecular Weight: 266.2649032
• Product Categories: Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 797054-19-4.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• CAS DataBase Reference: (1’R,2S)-2-[(1’,2’-O-Isopropylidene)dihydroxyethyl]-6-fluorochroman-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1’R,2S)-2-[(1’,2’-O-Isopropylidene)dihydroxyethyl]-6-fluorochroman-4-one(797054-19-4)
• EPA Substance Registry System: (1’R,2S)-2-[(1’,2’-O-Isopropylidene)dihydroxyethyl]-6-fluorochroman-4-one(797054-19-4)

Safety Data

• Hazardous Substances Data: 797054-19-4(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Upstream product

• 797054-16-1 (E)-(4R)-4,5-isopropylydene-dioxy-1-(2-hydroxy-5-fluoro-phenyl)-prop-2E-ene-1-one 
• 405-51-6 4-fluorophenyl acetate 
• 1707-77-3 1,2:5,6-di-O-isopropylidene-D-mannitol 
• 371-41-5 4-Fluorophenol 
• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 15186-48-8 2,3-isopropylidene-glyceraldehyde 

Downstream Products

• 303176-40-1 (R)-2-[(S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl-4-methylbenzenesulfonate 
• 303176-42-3 (R)-2-amino-1-[(S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]ethanol 
• 118457-14-0 (+)-Nebivolol 
• 303176-39-8 1-[6-fluoro-(2S)-3,4-dihydro-2H-benzopyran-2-yl]-(1R)-1,2-ethylene glycol 

Relevant articles and documents

Synthesis of (S,R,R,R)-α,α′-iminobis(methylene)bis(6- fluoro-3H,4H-dihydro-2H-1-benzopyran-2-methanol)

The β1-adrenergic antagonist (S,R,R,R)-α, α′-iminobis(methylene)bis(6-fluoro-3H,4H-dihydro-2H-1-benzopyran-2- methanol) was synthesized from natural chiral pool starting materials through an efficient, convergent synthetic strategy. The cyclization mechanism of the key step was investigated using computer modeling and is discussed. Georg Thieme Verlag Stuttgart.

NEW PROCESS FOR THE PREPARATION OF RACEMIC ([2S[2R*[R[R*]]]] and ([2R[2S*[S[S*]]]]-(±)- α,α' -[imino-bis(methylene)]bis[6-fluoro-chroman-2-methanol] AND ITS PURE [2S[2R*[R[R*]and

Process for the preparation of racemic ([2S[2R*[R[R*]]]]- and ([2R[2S*[S[S*]]]]-(±)- α,α' -[imino-bis(methylene)]bis[6-fluoro-chroman-2-methanol] of the compound of the formula (I) and its pure ([2S[2R*[R[R*]]]]- and ([2R[2S*[S[S*]]]]- enantiomer compounds characterized in that the products are prepared from 4--fluoro-phenole or 4-fluoro-anisole via crystalline, optically active intermediates.