30913-87-2

Basic information

• Product Name: 4-(4-BROMO-PHENYL)-4-OXO-BUTYRIC ACID ETHYL ESTER
• Synonyms: ETHYL 4-(4-BROMOPHENYL)-4-OXOBUTYRATE;4-(4-BROMO-PHENYL)-4-OXO-BUTYRIC ACID ETHYL ESTER;Benzenebutanoic acid, 4-broMo-g-oxo-, ethyl ester;Ethyl 4-(4-broMophenyl)-4-oxobutanoate;-4-oxobutanoate;Ethyl 4-(4-bromophenyl)
• CAS NO: 30913-87-2
• Molecular Formula: C₁₂H₁₃BrO₃
• Molecular Weight: 285.13
• Mol File: 30913-87-2.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 376.5°Cat760mmHg
• Flash Point: 181.5°C
• Appearance: /
• Density: 1.379g/cm³
• Vapor Pressure: 7.23E-06mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-(4-BROMO-PHENYL)-4-OXO-BUTYRIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-BROMO-PHENYL)-4-OXO-BUTYRIC ACID ETHYL ESTER(30913-87-2)
• EPA Substance Registry System: 4-(4-BROMO-PHENYL)-4-OXO-BUTYRIC ACID ETHYL ESTER(30913-87-2)

Safety Data

• Hazardous Substances Data: 30913-87-2(Hazardous Substances Data)

Usage

General Description

4-(4-Bromo-phenyl)-4-oxo-butyric acid ethyl ester is a chemical compound that consists of a butyric acid derivative with a bromo-substituted phenyl group attached to it. It is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds due to its versatile reactivity and functional groups. 4-(4-BROMO-PHENYL)-4-OXO-BUTYRIC ACID ETHYL ESTER is typically produced through esterification of 4-(4-bromo-phenyl)-4-oxo-butyric acid with ethanol, resulting in the formation of the ethyl ester. It is important to handle this chemical with care, as it is potentially hazardous and should only be used by trained professionals in a controlled laboratory setting.

InChI:InChI=1/C12H13BrO3/c1-2-16-12(15)8-7-11(14)9-3-5-10(13)6-4-9/h3-6H,2,7-8H2,1H3

Upstream product

• 766-96-1 4-bromo-1-ethynylbenzene 
• 41876-64-6 2-chloro-2-(4-bromophenyl)ethene 
• 623-51-8 ethyl 2-sulfanylacetate 
• 69151-18-4 1-bromo-4-(1-bromovinyl)benzene 
• 623-73-4 diazoacetic acid ethyl ester 
• 177750-12-8 N-{1-(4-bromophenyl)vinyl}acetamide 
• 59862-55-4 p-bromoacetophenone oxime 
• 99-90-1 para-bromoacetophenone 
• 105986-54-7 4-(4-bromophenyl)butylic acid ethyl ester 
• 35656-89-4 4-(4-bromophenyl)butanoic acid 
• 6340-79-0 4-oxo-4-(4-bromophenyl)butanoic acid 
• 108-86-1 bromobenzene 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 875433-19-5 4-(4-dec-1-ynyl-phenyl)-4-oxo-butyric acid ethyl ester 
• 875433-20-8 4-[4-(3-benzyloxy-prop-1-ynyl)-phenyl]-4-oxo-butyric acid ethyl ester 
• 1526926-30-6 C₁₆H₁₄O₂ 
• 126135-43-1 (R)-(+)-γ-(p-Bromophenyl)-γ-butyrolactone 
• 1020109-33-4 C₁₄H₁₇BrO₄ 
• 875433-18-4 4-[4-(3-hydroxy-prop-1-ynyl)-phenyl]-4-oxo-butyric acid ethyl ester 
• 375826-33-8 2-(4-bromophenyl)-5-ethoxythiophene 

Relevant articles and documents

Tetrakis(4-formylphenyl) ferrocene and preparation method and application thereof

The invention relates to the technical field of material synthesis, in particular to tetrakis(4-formylphenyl) ferrocene as well as a preparation method and application thereof. The preparation method comprises the following steps: in a nitrogen atmosphere, dropwise adding n-butyllithium into a tetrahydrofuran solution in which tetrakis(4-X-phenyl) ferrocene is dissolved, controlling the temperature and stirring, with the X being Br or I; then dropwise adding N,N-dimethylformamide, and after the N,N-dimethylformamide is completely added, controlling the temperature and stirring; transferring the reaction liquid into diluted hydrochloric acid, and stirring to separate out a solid; and filtering the separated solid, washing with methanol, re-dissolving the washed solid with ethyl acetate, and carrying out reduced pressure rotary evaporation on the obtained solution. The prepared tetrakis(4-formylphenyl) ferrocene can be condensed with aromatic amine to form an imine bond, so that a ferrocene structure is combined with a COFs structure to form a novel MCOFs material, the novel MCOFs material has excellent physical and chemical properties of ferrocene, a large number of metal active sites can be provided, and the structure is stable.

Nickel-Catalyzed Transformation of Diazoacetates to Alkyl Radicals Using Alcohol as a Hydrogen Source

A nickel-catalyzed transformation of diazoacetates to α-carbonyl methylene radicals has been disclosed in the presence of hyperoxide using ethanol as a hydrogen source and solvent. This strategy is successfully applied in the formation of indolin-2-ones or 1,4-dicarbonyl compounds from acrylamides or enamides in moderate to good yields. These reactions undergo radical addition onto C-C double bonds followed by a cyclization/oxidation or an oxidation/hydrolysis process, respectively.

A process for preparing γ - ketone carbonyl compounds

The present invention discloses a gamma-ketone carbonyl compound preparation method, wherein in the presence of an oxidizing agent, a styrene compound and ethyl diazoacetate are adopted as reactants, copper or a copper compound is adopted as a catalyst, DABCO is adopted as an alkali, and a free radical reaction is performed in a polar solvent isopropyl alcohol to obtain the product gamma-ketone carbonyl compound. According to the method of the present invention, the reaction activity of the catalyst is high, the reaction conditions are mild, the substrate application range is wide, the post-treatment is convenient, the yield of the target product is high, the preparation process is simple, and the sources of the used raw materials are wide.