30992-63-3

Basic information

• Product Name: 2-HYDROXY-5-BENZYLOXYACETOPHENONE
• Synonyms: 2-HYDROXY-5-BENZYLOXYACETOPHENONE;1-[2-Hydroxy-5-(phenylMethoxy)phenyl]ethanone;5'-Benzyloxy-2'-hydroxyacetophenone;Ethanone, 1-[2-hydroxy-5-(phenylMethoxy)phenyl]-
• CAS NO: 30992-63-3
• Molecular Formula: C₁₅H₁₄O₃
• Molecular Weight: 242.26986
• Product Categories: Aromatics Compounds;Aromatics
• Mol File: 30992-63-3.mol
• Article Data: 22

Chemical Properties

• Melting Point: 64-66°C
• Boiling Point: 391.2±27.0 °C(Predicted)
• Appearance: /
• Density: 1.187±0.06 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform, Dichloromethane, Ethyl Acetate, Methanol
• PKA: 10.52±0.20(Predicted)
• CAS DataBase Reference: 2-HYDROXY-5-BENZYLOXYACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-5-BENZYLOXYACETOPHENONE(30992-63-3)
• EPA Substance Registry System: 2-HYDROXY-5-BENZYLOXYACETOPHENONE(30992-63-3)

Safety Data

• Hazardous Substances Data: 30992-63-3(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

2-Hydroxy-5-benzyloxyacetophenone (cas# 30992-63-3) is a compound useful in organic synthesis.

Preparation

Preparation by reaction of benzyl chloride with quinacetophenone in refluxing acetone in the presence of potassium carbonate, with potassium iodide (85%) ; without potassium iodide (31%).

Upstream product

• 21766-81-4 1-[2',5'-bis(phenylmethoxy)phenyl]ethanone 
• 103-16-2 4-Benzyloxyphenol 
• 64-19-7 acetic acid 
• 121-71-1 3-Hydroxyacetophenone 
• 100-39-0 benzyl bromide 
• 584-08-7 potassium carbonate 
• 490-78-8 2,5-Dihydroxyacetophenone 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 100-44-7 benzyl chloride 

Downstream Products

• 111391-37-8 (E)-1-(5-Benzyloxy-2-hydroxy-phenyl)-3-(4-benzyloxy-phenyl)-propenone 
• 111391-42-5 (E)-1-(5-Benzyloxy-2-hydroxy-phenyl)-3-(4-methoxy-phenyl)-propenone 
• 171876-69-0 6-(benzyloxy)-2,2-dimethylchroman-4-one 
• 67978-81-8 5-benzyloxy-2-methoxyacetophenone 
• 861841-94-3 1‐[2-hydroxy-3-nitro-5-(benzyloxy)phenyl]ethanone 
• 203919-25-9 6-Benzyloxy-4-oxo-4H-chromen-3-carbaldehyde 
• 30992-65-5 6-benzyloxy-4-hydroxy-chromen-2-one 
• 109466-24-2 phenyl-2 5H-benzopyranno<1><4,3-d>pyrimidine 
• 947617-86-9 1'-benzyl-6-(benzyloxy)spiro[chromene-2,4'-piperidin]-4(3H)-one oxime 
• 86609-06-5 4-Benzyloxy-2-(1-hydroxy-1-phenyl-ethyl)-phenol 
• 138854-37-2 5-(benzyloxy)-2-(4-methoxybenzoyl)-3-methylbenzofuran 
• 88087-02-9 2-Benzoyloxy-5-benzyloxyacetophenone 
• 857554-47-3 (2-acetyl-4-benzyloxy-phenoxy)-acetic acid ethyl ester 

Relevant articles and documents

NOVEL COMPOUNDS AND THEIR USE

The present invention provides compounds of the general formula (I) or a pharmaceutically acceptable prodrugs, salts and/or solvates thereof, wherein LHS is selected from the group consisting of LHSa and LHSb And wherein, the asterisk (*) marks the point of attachment; These compounds exhibit antibacterial activity against Gram-negative and Gram-positive bacteria, especially S. aureus, E. coli, K. pneumoniae and A. baumannii. Pharmaceutical compositions containing these compounds, therapeutic uses thereof and methods for manufacturing the same are also provided.

Design, synthesis, and biological activity of a novel series of benzofuran derivatives against oestrogen receptor-dependent breast cancer cell lines

A docking study of a novel series of benzofuran derivatives with ERα was conducted. In this study, we report the synthesis of a novel series of benzofuran derivatives and evaluation of their anticancer activity in vitro against MCF-7 human breast cancer cells, as well as their potential toxicity to ER-independent MDA-MB-231 breast cancer cells, human renal epithelial HEK-293 cells, and human immortal keratinocytes (HaCaT cells) by using the MTT colorimetric assay. The screening results indicated that the target compounds exhibited anti-breast cancer activity. The target compound 2-benzoyl-3-methyl-6-[2-(morpholin-4-yl)ethoxy]benzofuran hydrochloride (4e) exhibited excellent activity against anti-oestrogen receptor-dependent breast cancer cells and low toxicity. The preliminary structure-activity relationships of the target benzofuran derivatives have been summarised. In conclusion, the novel benzofuran scaffold may be a promising lead for the development of potential oestrogen receptor inhibitors.

5-[2-hydroxy-3-(alkylamine) propoxy] benzofuran compound and application thereof

The invention belongs to the technical field of medicines and relates to a 5-[2-hydroxy-3-(alkylamine) propoxy] benzofuran compound and the application thereof. The 5-[2-hydroxy-3-(alkylamine) propoxy] benzofuran compound comprises a stereisomer of the compound and pharmaceutically applicable salt; the general molecular formula of the compound is shown as follows: wherein R is described as the claims and the specification. The 5-[2-hydroxy-3-(alkylamine) propoxy] benzofuran compound and the pharmaceutically applicable acid addition salt of the compound can be combined with the existing drug for use or can be used alone, and are used for preparing a drug for treating a vascular smooth muscle spastic disease.