32327-68-7

Basic information

• Product Name: 1-(2-chloroethyl)-4-methylbenzene
• CAS NO: 32327-68-7
• Molecular Formula: C₉H₁₁Cl
• Molecular Weight: 154.6366
• Mol File: 32327-68-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 221°C at 760 mmHg
• Flash Point: 85.2°C
• Density: 1.031g/cm³
• Vapor Pressure: 0.163mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: 1-(2-chloroethyl)-4-methylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloroethyl)-4-methylbenzene(32327-68-7)
• EPA Substance Registry System: 1-(2-chloroethyl)-4-methylbenzene(32327-68-7)

Safety Data

• Hazardous Substances Data: 32327-68-7(Hazardous Substances Data)

Usage

Description

1-(2-chloroethyl)-4-methylbenzene, also known as 4-(2-Chloroethyl)toluene, is a chemical compound characterized by the molecular formula C9H11Cl. It is a colorless liquid featuring a chloroethyl group and a methyl group attached to a benzene ring, which contributes to its versatile applications in various industries.

Uses

Used in Pharmaceutical Synthesis:
1-(2-chloroethyl)-4-methylbenzene is used as an intermediate for the synthesis of pharmaceuticals, leveraging its chemical structure to create a range of medicinal compounds.
Used in Agrochemical Production:
In the agrochemical industry, 1-(2-chloroethyl)-4-methylbenzene is utilized as a starting material for the development of various agrochemicals, playing a crucial role in agricultural product formulation.
Used in Dye and Perfume Manufacturing:
1-(2-chloroethyl)-4-methylbenzene is also employed in the production of dyes and perfumes, where its chemical properties contribute to the creation of diverse colorants and fragrances.
Used as a Solvent for Resins:
1-(2-chloroethyl)-4-methylbenzene serves as a solvent for resins, facilitating the manufacturing process and improving the end product's quality.
Used in the Synthesis of Other Organic Compounds:
As a common intermediate, 1-(2-chloroethyl)-4-methylbenzene is also used in the synthesis of other organic compounds, highlighting its importance in the chemical industry.
Used in Industrial Chemical Manufacturing:
1-(2-chloroethyl)-4-methylbenzene is a key intermediate in the manufacturing of various industrial chemicals, underlining its broad applicability across different sectors.
Safety Precautions:
It is important to handle 1-(2-chloroethyl)-4-methylbenzene with care due to its toxic, flammable nature, and potential to cause skin and eye irritation upon contact. Proper safety measures should be taken to minimize risks during its use and storage.

Upstream product

• 80-41-1 2-chloroethyl tosylate 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 593-71-5 Chloroiodomethane 
• 104-87-0 4-methyl-benzaldehyde 
• 6749-78-6 4-methylphenylmagnesium iodide 
• 84648-16-8 C₁₇H₁₅ClO₄ 
• 13290-16-9 2-(p-tolylthio)-ethanol 
• 14503-40-3 2-(4-methylphenyl)ethyl tosylate 
• 699-02-5 4-Methylphenethyl alcohol 

Downstream Products

• 622-97-9 1-ethenyl-4-methylbenzene 
• 109395-33-7 1-Phenyl-3-<4-tolyl>-propylcyanid 
• 622-96-8 4-methylethylbenzene 
• 14087-97-9 7-methyl-2-phenyl-3,4-dihydro-2H-naphthalen-1-one 
• 108976-74-5 2-phenyl-4-p-tolyl-butyric acid 
• 1391611-30-5 C₂₃H₂₀N₂O 
• 1391611-27-0 C₂₃H₂₀N₂O 
• 256475-58-8 1-(2-p-tolyl-ethyl)-[1,4]diazepane 
• 59698-41-8 N-[2-(4-methylphenyl)ethyl]piperazine 
• 79744-75-5 4-methyl-1-methoxyethylbenzene 
• 104-87-0 4-methyl-benzaldehyde 
• 103790-59-6 1-(2-methoxyethyl)-4-methylbenzene 

Relevant articles and documents

Chemoselective Homologation-Deoxygenation Strategy Enabling the Direct Conversion of Carbonyls into (n+1)-Halomethyl-Alkanes

The sequential installation of a carbenoid and a hydride into a carbonyl, furnishing halomethyl alkyl derivatives, is reported. Despite the employment of carbenoids as nucleophiles in reactions with carbon-centered electrophiles, sp3-type alkyl halides remain elusive materials for selective one-carbon homologations. Our tactic levers on using carbonyls as starting materials and enables uniformly high yields and chemocontrol. The tactic is flexible and is not limited to carbenoids. Also, diverse carbanion-like species can act as nucleophiles, thus making it of general applicability.

Non-imidazole histamine H3 ligands. Part I. Synthesis of 2-(1-piperazinyl)- and 2-(hexahydro-1H-1,4-diazepin-1-yl)benzothiazole derivatives as H3-antagonists with H1 blocking activities

New 2-(1-Piperazinyl)- and 2-(hexahydro-1H-1,4-diazepin-1-yl)benzothiazoles were prepared and tested as H1- and H3-receptor antagonists. A number of compounds showed weak H1-antagonistic activity, with pA2 values ranging from 5.5 to 6.1. The simple alkyl substituted, 2-[1-(4-methyl and 4-ethyl)piperazinyl] analogues show increasing, moderate H3-antagonistic activity (pA2=6.0, and pA2=7.0). The compounds with 4-phenylalkyl substitution, for both the piperazinyl and the hexahydro-1H-1,4-diazepin-1-yl homologues series, regardless of the different physicochemical properties of the para substituents at the phenyl ring, showed weak H3-antagonistic activity with pA2 values ranging from 4.4 to 5.6. Copyright (C) 1999 Elsevier Science S.A.

Structure of ω-Arylalkyl Radicals: A 13C CIDNP Investigation

Thermolysis of a series of ω-arylalkanoyl m-chlorobenzoyl (and acetyl) peroxides at ca. 100 deg C in cyclohexanone and in hexachloroacetone was studied by using 13C chemically induced dynamic nuclear polarization.Analysis of the observed 13C polarizations indicate that all the three radicals (β-arylethyl, γ-arylpropyl and δ-arylbutyl) have open-chain structures with no evidence for aryl participation resulting in spirocycloalkylcyclohexadienyl radicals.