3250-74-6

Basic information

• Product Name: 3-(2H-TETRAZOL-5-YL)-PYRIDINE
• Synonyms: 5-(3-PYRIDYL)-1H-TETRAZOLE;5-(3-PYRIDYL)TETRAZOLE;AKOS B020828;3-(2H-TETRAZOL-5-YL)-PYRIDINE;3-(2H-TETRAAZOL-5-YL)PYRIDINE;BUTTPARK 14\02-73;ART-CHEM-BB B020828;IFLAB-BB F2124-0755
• CAS NO: 3250-74-6
• Molecular Formula: C₆H₅N₅
• Molecular Weight: 147.14
• EINECS: 426-810-8
• Product Categories: MOFS COFS
• Mol File: 3250-74-6.mol
• Article Data: 47

Chemical Properties

• Melting Point: 240 °C
• Boiling Point: 379.4 °C at 760mmHg
• Flash Point: 192.2 °C
• Appearance: /
• Density: 1.39 g/cm³
• Vapor Pressure: 5.88E-06mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 5.99±0.12(Predicted)
• Water Solubility: Soluble in water (slightly).
• CAS DataBase Reference: 3-(2H-TETRAZOL-5-YL)-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2H-TETRAZOL-5-YL)-PYRIDINE(3250-74-6)
• EPA Substance Registry System: 3-(2H-TETRAZOL-5-YL)-PYRIDINE(3250-74-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 26-36/37/39-36
• WGK Germany: 3
• HazardClass: IRRITANT-HARMFUL
• Hazardous Substances Data: 3250-74-6(Hazardous Substances Data)

Usage

Description

3-(2H-TETRAZOL-5-YL)-PYRIDINE is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals. It is characterized by its unique molecular structure, which features a tetrazole ring fused to a pyridine ring. 3-(2H-TETRAZOL-5-YL)-PYRIDINE is known for its reactivity and is often utilized in chemical reactions to produce a wide range of pharmaceutically relevant molecules.

Uses

Used in Pharmaceutical Industry:
3-(2H-TETRAZOL-5-YL)-PYRIDINE is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique structure allows it to participate in a range of chemical reactions, making it a versatile building block in the development of new medications.
Used in Synthesis of 1-(4-bromo-phenyl)-3-(5-pyridin-3-yl-tetrazol-2-yl)-propan-1-one:
3-(2H-TETRAZOL-5-YL)-PYRIDINE is used as a reactant in the synthesis of 1-(4-bromo-phenyl)-3-(5-pyridin-3-yl-tetrazol-2-yl)-propan-1-one, a compound with potential pharmaceutical applications. The reaction involves the use of 1-(4-bromo-phenyl)-3-piperidino-propan-1-one, hydrochloride, and dimethylformamide as a solvent. The process requires a reaction time of 8 hours at a temperature of 150°C, yielding a product with a 31% yield.

InChI:InChI=1/C6H4N5/c1-2-5(4-7-3-1)6-8-10-11-9-6/h1-4H/q-1

Upstream product

• 1120-90-7 3-iodopyridine 
• 1193-92-6 3-pyridinealdoxime 
• 500-22-1 3-pyridinecarboxaldehyde 
• 626-55-1 3-Bromopyridine 
• 100-54-9 pyridine-3-carbonitrile 
• 4648-54-8 trimethylsilylazide 

Downstream Products

• 54584-54-2 N-phenyl-5-(pyridin-3-yl)-1,3,4-oxadiazol-2-amine 
• 132766-76-8 5-(3-pyridyl)tetrazole-2-acetic acid 
• 1022089-84-4 3-(5-pyridine-3-yl-[1,3,4]oxadiazol-2-yl)-benzonitrile 

Relevant articles and documents

Synthesis and Photochemical Properties of Manganese(I) Tricarbonyl Diimine Complexes Bound to Tetrazolato Ligands

Ten manganese(I) tricarbonyl diimine complexes bound to variably functionalised 5-aryl-tetrazolato ligands were prepared, and their photochemical properties were investigated. Upon exposure to light at 365 nm, each complex decomposed to its free diimine and tetrazolato ligands, simultaneously dissociating three CO ligands, as evidenced by changes in the IR spectra of the irradiated complexes over time. The anti-bacterial properties of one of these complexes were tested against Escherichia coli. While the complex displayed no effect on the bacterial growth in the dark, pre-irradiated solutions inhibited bacterial growth. Comparative studies revealed that the antibacterial properties originate from the presence of free 1,10-phenanthroline.

Biosynthesis of Pd/MnO2 nanocomposite using Solanum melongena plant extract and its application for the one-pot synthesis of 5-substituted 1H-tetrazoles from aryl halides

In this work, for the first time, Solanum melongena plant extract was used for the green synthesis of Pd/MnO2 nanocomposite via reduction osf Pd(II) ions to Pd(0) and their immobilization on the surface of manganese dioxide (MnO2) nanoparticles (NPs) as an effective support. The synthesized nanocomposite were characterized by various analytical techniques such as Fourier transform infrared (FT-IR), X-ray diffraction (XRD), transmission electron microscopy (TEM), field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectroscopy (EDS) and UV–Vis spectroscopy. The catalytic activity of Pd/MnO2 nanocomposite was used as a heterogeneous catalyst for the one-pot synthesis of 5-substituted 1H-tetrazoles from aryl halides containing various electron-donating or electron-withdrawing groups in the presence of K4[Fe (CN)6] as non-toxic cyanide source and sodium azide. The products were obtained in good yields via a simple methodology and easy work-up. The nanocatalyst can be recycled and reused several times with no remarkable loss of activity.

Enantiomerism, diastereomerism and thermochromism in two Cu7I4 cluster-based coordination polymers

Solvothermal reaction between CuI and 5-(3-pyridyl)tetrazole (HPTA) in CH3CN and NH3·H2O/n-BuOH, afforded two kinds of Cu7I4 cluster-based coordination polymers 1 and 2, respectively. 1 is a racemic conglomerate of enantiomers crystallizing in the P6322 space group and 2 is a mesomer crystallizing in the P3c1 group. Both 1 and 2 show dual-channel emissions in which low-energy emission originates from a cluster-centered (CC) excited state while high-energy emission is attributed to an iodide-to-ligand charge transfer (XLCT)/metal-to-ligand charge transfer (MLCT) excited state. Of particular interest, 2 exhibits thermochromic luminescence originating from the combined effects of non-radiative transition and thermal deactivation of the XLCT excited state.