32587-80-7Relevant articles and documents
Copper-catalyzed enantioselective conjugate addition of Grignard reagents to acyclic enones
Lopez, Fernando,Harutyunyan, Syuzanna R.,Minnaard, Adriaan J.,Feringa, Ben L.
, p. 12784 - 12785 (2004)
A highly enantioselective Cu-catalyzed addition of Grignard reagents to acyclic aliphatic enones is described. In the presence of 5 mol % of CuBr·SMe2 and 6 mol % of JosiPhos diphosphine aliphatic enones react with Grignard reagents to provide β-substituted linear ketones with high yields, regio-, and enantioselectivities. Copyright
Successive 1,4- and 1,2-additions of organometallic reagents to a chiral binaphthyl ester: One step synthesis of optically active ketones
Fuji,Tanaka,Mizuchi,Hosoi
, p. 7277 - 7280 (1991)
Organometallic reagents undergo a 1,4-addition onto the chiral binaphthyl ester of α,β-unsaturated carboxylic acid followed by the formal 1,2-addition to yield optically active ketones directly.
Chiral-Anion-Mediated Asymmetric Heck-Matsuda Reaction of Acyclic Alkenyl Alcohols
Zhang, Tao,Li, Wen-Ao,Shen, Hong-Cheng,Chen, Shu-Sen,Han, Zhi-Yong
supporting information, p. 1473 - 1477 (2021/03/08)
Acyclic internal alkenes are a class of challenging substrates in asymmetric Heck-type reactions due to difficulties related to both reactivity and selectivity control. Employing acyclic alkenyl alcohols, an asymmetric Heck-Matsuda reaction is developed through the strategy of chiral anion phase transfer. Various chiral ketones could be obtained in high levels of enantioselectivity. A catalytic amount of dimethyl sulfoxide (DMSO) as an additive is crucial for the reaction to suppress the palladium-hydride-mediated side reactions.
Asymmetric Umpolung Hydrogenation and Deuteration of Alkenes Catalyzed by Nickel
Guo, Siyu,Wang, Xiuhua,Zhou, Jianrong Steve
supporting information, p. 1204 - 1207 (2020/02/04)
Nickel-catalyzed asymmetric hydrogenation of several types of alkenes proceeds in high enantioselectivity, using acetic acid or water as the hydrogen source and indium powder as electron donor. The scope of alkenes herein include α,β-unsaturated esters, n