327617-82-3

Basic information

• Product Name: 4-CHLORO-1-OXO-1-(4-TRIFLUOROMETHYLPHENYL)BUTANE
• Synonyms: 4-CHLORO-1-OXO-1-(4-TRIFLUOROMETHYLPHENYL)BUTANE
• CAS NO: 327617-82-3
• Molecular Formula: C₁₁H₁₀ClF₃O
• Molecular Weight: 250.64
• Mol File: 327617-82-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 310.1°C at 760 mmHg
• Flash Point: 141.3°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 0.000613mmHg at 25°C
• Refractive Index: 1.468
• CAS DataBase Reference: 4-CHLORO-1-OXO-1-(4-TRIFLUOROMETHYLPHENYL)BUTANE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-1-OXO-1-(4-TRIFLUOROMETHYLPHENYL)BUTANE(327617-82-3)
• EPA Substance Registry System: 4-CHLORO-1-OXO-1-(4-TRIFLUOROMETHYLPHENYL)BUTANE(327617-82-3)

Safety Data

• Hazardous Substances Data: 327617-82-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H10ClF3O/c12-7-1-2-10(16)8-3-5-9(6-4-8)11(13,14)15/h3-6H,1-2,7H2

Upstream product

• 402-51-7 4-(trifluoromethyl)phenylmagnesium bromide 
• 4635-59-0 4-Chlorobutanoyl chloride 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 29480-10-2 1-(4-(trifluoromethyl)phenyl)cyclobutan-1-ol 

Downstream Products

• 61718-86-3 5-oxo-5-[4-(trifluoromethyl)phenyl]pentanenitrile 
• 215667-88-2 4-iodo-1-(4-trifluoromethylphenyl)butanone 

Relevant articles and documents

Manganese-Catalyzed Electrochemical Deconstructive Chlorination of Cycloalkanols via Alkoxy Radicals

A manganese-catalyzed electrochemical deconstructive chlorination of cycloalkanols has been developed. This electrochemical method provides access to alkoxy radicals from alcohols and exhibits a broad substrate scope, with various cyclopropanols and cyclobutanols converted into synthetically useful β- and γ-chlorinated ketones (40 examples). Furthermore, the combination of recirculating flow electrochemistry and continuous inline purification was employed to access products on a gram scale.

New efficient nickel-catalyzed cross-coupling reaction between two Csp3 centers

The presence of a remote unsaturation (double bond, carbonyl group, cyano group) in an alkyl halide facilitates its cross-coupling reaction with various diorganozincs in the presence of Ni(acac)2 (7.5-10 mol % in THF/NMP mixtures). These results were used to develop a new general cross-coupling reaction between functionalized diorganozincs and alkyl iodides using m- or p-trifluoromethylstyrene as a reaction promotor and Ni(acac)2 as a catalyst (7.5-10 mol %; -35 °C, 5-10 h) leading to a broad range of polyfunctional cross-coupling products.