35554-38-2

Basic information

• Product Name: Benzoic acid, 4-(2,2,2-trifluoroethoxy)-, methyl ester
• CAS NO: 35554-38-2
• Molecular Formula: C10H9F3O3
• Molecular Weight: 234.175
• Mol File: 35554-38-2.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-(2,2,2-trifluoroethoxy)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(2,2,2-trifluoroethoxy)-, methyl ester(35554-38-2)
• EPA Substance Registry System: Benzoic acid, 4-(2,2,2-trifluoroethoxy)-, methyl ester(35554-38-2)

Safety Data

• Hazardous Substances Data: 35554-38-2(Hazardous Substances Data)

Upstream product

• 75-89-8 2,2,2-trifluoroethanol 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 67-56-1 methanol 
• 75-77-4 chloro-trimethyl-silane 
• 27914-56-3 4-(2,2,2-trifluoroethoxy)benzoic acid 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 420-87-1 sodium 2,2,2-trifluoroethanolate 

Downstream Products

• 50778-60-4 4-(2',2',2'-Trifluoroethoxy)benzamide 
• 1192829-76-7 3-chloro-4-(2,2,2-trifluoroethoxy)benzoic acid 
• 864178-59-6 3-chloro-4-(2,2,2-trifluoro-ethoxy)-benzoic acid methyl ester 

Relevant articles and documents

Light-Promoted Nickel Catalysis: Etherification of Aryl Electrophiles with Alcohols Catalyzed by a NiII-Aryl Complex

A highly effective C?O coupling reaction of (hetero)aryl electrophiles with primary and secondary alcohols is reported. Catalyzed by a NiII-aryl complex under long-wave UV (390–395 nm) irradiation in the presence of a soluble amine base without any additional photosensitizer, the reaction enables the etherification of aryl bromides and aryl chlorides as well as sulfonates with a wide range of primary and secondary aliphatic alcohols, affording synthetically important ethers. Intramolecular C?O coupling is also possible. The reaction appears to proceed via a NiI–NiIII catalytic cycle.

INHIBITORS OF RHO/MRTF/SRF-MEDIATED GENE TRANSCRIPTION AND METHODS FOR USE OF THE SAME

Disclosed herein are inhibitors of Rho/MRTF/SRF-mediated gene transcription, and methods for their use in treating or preventing diseases such as cancer and fibrosis. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically accept

I 2 /TBHP-Promoted Approach to α-Keto Esters from Trifluoromethyl β-Diketones and Alcohols via C-C Bond Cleavage

A metal-free oxidative coupling reaction of trifluoromethyl β-diketones with alcohols for the synthesis of α-keto esters in good to excellent yields has been developed. Preliminary mechanistic studies suggest that an I 2 /TBHP promoted sequential iodination, C-C bond cleavage, C-O bond formation and oxidation pathway is involved in this reaction.