3611-72-1

Basic information

• Product Name: cloridarol
• Synonyms: cloridarol;clobenfurol;2-Benzofuryl-p-chlorophenylcarbinol;Chloridarol;Menacor;Menoxicor;1-benzofuran-2-yl-(4-chlorophenyl)methanol;benzofuran-2-yl-(4-chlorophenyl)methanol
• CAS NO: 3611-72-1
• Molecular Formula: C15H11ClO2
• Molecular Weight: 258.703
• EINECS: 222-780-3
• Mol File: 3611-72-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 48-49°
• Boiling Point: 410.5°Cat760mmHg
• Flash Point: 202.1°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 1.78E-07mmHg at 25°C
• Refractive Index: 1.657
• CAS DataBase Reference: cloridarol(CAS DataBase Reference)
• NIST Chemistry Reference: cloridarol(3611-72-1)
• EPA Substance Registry System: cloridarol(3611-72-1)

Safety Data

• Hazardous Substances Data: 3611-72-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H11ClO2/c16-12-7-5-10(6-8-12)15(17)14-9-11-3-1-2-4-13(11)18-14/h1-9,15,17H

Upstream product

• 90-02-8 salicylaldehyde 
• 637-87-6 1-Chloro-4-iodobenzene 
• 4265-16-1 2-formylbenzo[b]furan 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 271-89-6 1-benzofurane 
• 104-88-1 4-chlorobenzaldehyde 
• 27052-20-6 (1-benzofuran-2-yl)(4-chlorophenyl)methanone 

Relevant articles and documents

Catalytic Aldehyde and Alcohol Arylation Reactions Facilitated by a 1,5-Diaza-3,7-diphosphacyclooctane Ligand

We report a catalytic method to access secondary alcohols by the coupling of aryl iodides. Either aldehydes or alcohols can be used as reaction partners, making the transformation reductive or redox-neutral, respectively. The reaction is mediated by a Ni catalyst and a 1,5-diaza-3,7-diphosphacyclooctane. This P2N2ligand, which has previously been unrecognized in cross-coupling and related reactions, was found to avoid deleterious aryl halide reduction pathways that dominate with more traditional phosphines and NHCs. An interrupted carbonyl-Heck type mechanism is proposed to be operative, with a key 1,2-insertion step forging the new C-C bond and forming a nickel alkoxide that may be turned over by an alcohol reductant. The same catalyst was also found to enable synthesis of ketone products from either aldehydes or alcohols, demonstrating control over the oxidation state of both the starting materials and products.

Deprotonation of furans using lithium magnesates

Furan was deprotonated on treatment with 1/3 equiv of Bu3MgLi in THF at rt. The lithium arylmagnesate formed was either trapped with electrophiles or involved in a palladium-catalyzed cross-coupling reaction with 2-bromopyridine. The highly coordinated magnesate Bu4MgLi2 (1/3 equiv) proved to be a better deprotonating agent than Bu3MgLi; the monitoring of the reaction using NMR spectroscopy showed that the deprotonation of furan at rt required 2 h whereas the subsequent electrophilic trapping was instantaneous. The method was extended to benzofuran, allowing its functionalization at C2 in high yields. The deprotonation of 2-methylfuran and lithium furfurylalkoxide at C5 turned out to be difficult, requiring either long reaction times or higher temperatures.

Comparison of antibacterial properties of halogeno aroylbenzofurans and corresponding

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