367-11-3 Usage
Description
1,2-Difluorobenzene, also known as o-difluorobenzene, is a colorless liquid with the chemical formula C6H4F2. It is a difluorobenzene derivative carrying fluoro groups at positions 1 and 2. 1,2-Difluorobenzene undergoes defluorination under very mild conditions by H2 in the presence of NaOAc over rhodium pyridylphosphine and bipyridyl complexes tethered on a silica-supported palladium catalyst.
Uses
1. Used in Electrochemical Analysis:
1,2-Difluorobenzene is used as a solvent in electrochemical studies on transition metal complexes. It serves as a potent inhibitor of NMDA receptors, making it valuable for studying the mechanisms and interactions of these receptors in various applications.
2. Used in Pharmaceutical Industry:
1,2-Difluorobenzene is used as a potent inhibitor of NMDA receptors, which are involved in various neurological processes and disorders. Its inhibitory properties make it a useful compound for the development of drugs targeting these receptors, potentially leading to treatments for conditions such as epilepsy, chronic pain, and neurodegenerative diseases.
3. Used in Analytical Chemistry:
1,2-Difluorobenzene has been employed in the study of the mechanism of dissociation of o-, m-, and p-difluorobenzene ions by threshold photoelectron photoion coincidence spectroscopy. This application helps researchers understand the behavior of these compounds at the molecular level, which can be useful for developing new analytical techniques and understanding chemical reactions.
4. Used in Surface Science:
1,2-Difluorobenzene has been used to study the room temperature adsorption of 1,2-DFB, 1,2-dichlorobenzene, and 1,2-dibromobenzene on Si(100)2x1 by X-ray photoelectron spectroscopy and temperature programmed desorption. These studies contribute to the understanding of adsorption processes and surface interactions, which are crucial for various applications in materials science and nanotechnology.
Check Digit Verification of cas no
The CAS Registry Mumber 367-11-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,6 and 7 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 367-11:
(5*3)+(4*6)+(3*7)+(2*1)+(1*1)=63
63 % 10 = 3
So 367-11-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H4F2/c7-5-3-1-2-4-6(5)8/h1-4H
367-11-3Relevant articles and documents
Shaw,Hyman
, p. 1563 (1969)
Three-step regioselective synthesis of 2,3-difluorohalobenzenes using tetrafluoroethylene and buta-1,3-diene as starting building blocks
Egorov, M. P.,Lipkind, M. B.,Nefedov, O. M.,Volchkov, N. V.
, p. 925 - 932 (2021/06/07)
The gas-phase copyrolysis of tetrafluoroethylene and buta-1,3-diene in a flow tube reactor at 490–510 °C gives 3,3,4,4-tetrafluorocyclohex-1-ene, which is selectively converted to 1-bromo- or 1-chloro-2,3-difluorobenzene via intermediate steps of halogenation and dehydrohalogenation.
Two-step regioselective synthesis of 1,2-difluorobenzenes from chlorotrifluoroethylene and buta-l,3-dienes
Lipkind, M. B.,Nefedov, O. M.,Volchkov, N. V.
, p. 68 - 75 (2020/04/21)
The gas-phase copyrolysis of chlorotrifluoroethylene with buta-1,3-diene, penta-1,3-diene, or isoprene in a flow reactor at 440–480°C gave 4-chloro-4,5,5-trifluorocyclohex-1-enes. The latter treated with aqueous KOH under condition of phase-transfer catalysis were selectively converted into 1,2-difluorobenzene, 2,3-difluorotoluene, or 3,4-difluorotoluene.