37069-08-2

Basic information

• Product Name: 1-(4-BENZOOXAZOL-2-YL-PHENYL)-ETHANONE
• Synonyms: 1-(4-BENZOOXAZOL-2-YL-PHENYL)-ETHANONE
• CAS NO: 37069-08-2
• Molecular Formula: C₁₅H₁₁NO₂
• Molecular Weight: 237.257
• Mol File: 37069-08-2.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-BENZOOXAZOL-2-YL-PHENYL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-BENZOOXAZOL-2-YL-PHENYL)-ETHANONE(37069-08-2)
• EPA Substance Registry System: 1-(4-BENZOOXAZOL-2-YL-PHENYL)-ETHANONE(37069-08-2)

Safety Data

• Hazardous Substances Data: 37069-08-2(Hazardous Substances Data)

Usage

Description

1-(4-Benzooxazol-2-yl-phenyl)-ethanone, also known as 2-oxo-1-(4-benzooxazol-2-yl-phenyl)ethanone, is a chemical compound with the molecular formula C15H9NO3. It is a yellow crystalline solid that has a melting point of 164-166°C. 1-(4-BENZOOXAZOL-2-YL-PHENYL)-ETHANONE is utilized in the synthesis of various organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals. It has also been studied for its potential biological activities, such as anti-inflammatory and anti-cancer properties, and has been investigated for its role in the development of new materials and polymers. Overall, 1-(4-benzooxazol-2-yl-phenyl)-ethanone has potential applications in various fields and continues to be the subject of scientific research.

Uses

Used in Pharmaceutical Industry:
1-(4-Benzooxazol-2-yl-phenyl)-ethanone is used as a key intermediate in the synthesis of pharmaceuticals for its potential anti-inflammatory and anti-cancer properties. It contributes to the development of new drugs that can help in the treatment of various diseases.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(4-Benzooxazol-2-yl-phenyl)-ethanone is used as a building block for the creation of new agrochemicals. Its synthesis capabilities allow for the development of innovative products that can enhance crop protection and yield.
Used in Specialty Chemicals:
1-(4-Benzooxazol-2-yl-phenyl)-ethanone is utilized as a crucial component in the production of specialty chemicals. Its unique properties enable the creation of tailored chemical products for specific applications, such as dyes, pigments, and additives.
Used in Material Science:
1-(4-BENZOOXAZOL-2-YL-PHENYL)-ETHANONE is also used as a component in the development of new materials and polymers. Its integration into the field of material science allows for the creation of advanced materials with improved properties, such as enhanced strength, durability, or chemical resistance.
Overall, 1-(4-Benzooxazol-2-yl-phenyl)-ethanone is a versatile chemical compound with a wide range of applications across different industries, including pharmaceuticals, agrochemicals, specialty chemicals, and material science. Its potential biological activities and its role in the synthesis of various organic compounds make it a valuable asset in the ongoing research and development efforts in these fields.

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Relevant articles and documents

Bimetallic Cooperative Catalysis for Decarbonylative Heteroarylation of Carboxylic Acids via C-O/C-H Coupling

Cooperative bimetallic catalysis is a fundamental approach in modern synthetic chemistry. We report bimetallic cooperative catalysis for the direct decarbonylative heteroarylation of ubiquitous carboxylic acids via acyl C-O/C-H coupling. This novel catalytic system exploits the cooperative action of a copper catalyst and a palladium catalyst in decarbonylation, which enables highly chemoselective synthesis of important heterobiaryl motifs through the coupling of carboxylic acids with heteroarenes in the absence of prefunctionalization or directing groups. This cooperative decarbonylative method uses common carboxylic acids and shows a remarkably broad substrate scope (>70 examples), including late-stage modification of pharmaceuticals and streamlined synthesis of bioactive agents. Extensive mechanistic and computational studies were conducted to gain insight into the mechanism of the reaction. The key step involves intersection of the two catalytic cycles via transmetallation of the copper–aryl species with the palladium(II) intermediate generated by oxidative addition/decarbonylation.

Direct C—H Bond Activation of Benzoxazole and Benzothiazole with Aryl Bromides Catalyzed by Palladium(II)-N-heterocyclic Carbene Complexes

Herein, we report that a series of novel palladium(II)-NHC complexes (NHC=N-heterocyclic carbene) were synthesized. The structures of all novel complexes were characterized by 1H NMR, 13C NMR, FT-IR spectroscopy and elemental analysis techniques. These palladium(II)-NHC complexes were tested as efficient catalysts in the direct C—H bond activation of benzoxazole and benzothiazole with aryl bromides in the presence of 1 mol% catalyst loading at 150 °C for 4 h. Under the given conditions, various aryl bromides were successfully applied as the arylating reagents to achieve the 2-arylbenzoxazoles and 2-arylbenzothiazoles in acceptable to high yields.

High-Throughput Screening Protocol for the Coupling Reactions of Aryl Halides Using a Colorimetric Chemosensor for Halide Ions

Mercury complex of 4-(2-pyridylazo)resorcinol (PAR-2Hg2+), a halide-ion chemosensor, was prepared and its efficiency as a tool for high-throughput screening (HTS) of transition-metal-catalyzed coupling reactions was investigated. It showed a high selectivity for halide ions. When the PAR-2Hg2+ complex was used in the Suzuki coupling reaction and C-H activated coupling reaction with aryl bromides, the quantitative and qualitative conversions of aryl halides were obtained from the reaction mixture color change.