38035-81-3

Basic information

• Product Name: 3-phenylquinolin-2(1H)-one
• Synonyms: 3-phenyl-2-quinolone
• CAS NO: 38035-81-3
• Molecular Formula: C₁₅H₁₁NO
• Molecular Weight: 221.2539
• Mol File: 38035-81-3.mol
• Article Data: 44

Chemical Properties

• Boiling Point: 445.4°C at 760 mmHg
• Flash Point: 266.6°C
• Density: 1.2g/cm³
• Vapor Pressure: 3.96E-08mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: 3-phenylquinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenylquinolin-2(1H)-one(38035-81-3)
• EPA Substance Registry System: 3-phenylquinolin-2(1H)-one(38035-81-3)

Safety Data

• Hazardous Substances Data: 38035-81-3(Hazardous Substances Data)

Upstream product

• 19319-28-9 (Z)-3-(2-chlorophenyl)-2-phenyl acrylic acid 
• 1035669-85-2 C₁₇H₁₅NO 
• 1666-96-2 3-phenylquinoline 
• 19319-35-8 (E)-2-phenyl-3-(2-nitrophenyl)propenoic acid 
• 36926-84-8 3-(phenyl)quinolin-2-amine 
• 25308-72-9 3-phenylquinoline N-oxide 
• 103-83-3 N,N'-dimethylbenzylamine 
• 260783-80-0 N,N,N--trimethyl--1--phenylmethanaminium trifluoromethanesulfonate 
• 552-89-6 2-nitro-benzaldehyde 
• 13939-06-5 molybdenum hexacarbonyl 
• 529-23-7 o-aminobenzaldehyde 
• 100-44-7 benzyl chloride 
• 95-53-4 o-toluidine 
• 13141-38-3 2-phenylethynylaniline 

Downstream Products

• 2859-30-5 2-chloro-3-phenyl-quinoline 
• 1254212-16-2 3-phenyl-2-(3-phenylquinolin-2-yloxy)quinoline 
• 78597-76-9 5-(1,2-Dihydro-2-oxo-3-phenylquinol-1-yl)-valeric acid ethyl ester 
• 78587-98-1 1,2-dihydro-2-oxo-3-phenylquinol-1-yl-acetic acid ethyl ester 
• 113093-00-8 2-[4-(3-Phenyl-quinolin-2-yl)-piperazin-1-yl]-ethanol 
• 113092-99-2 2-(4-Ethyl-piperazin-1-yl)-3-phenyl-quinoline 
• 113092-98-1 2-(4-Methyl-piperazin-1-yl)-3-phenyl-quinoline 
• 113092-97-0 3-Phenyl-2-piperazin-1-yl-quinoline 
• 841303-92-2 4-(3-phenyl-quinolin-2-yl)-benzaldehyde 
• 841303-91-1 trifluoro-methanesulfonic acid 3-phenyl-quinolin-2-yl ester 
• 57876-69-4 2-chloro-3-methyl-quinoline 

Relevant articles and documents

Palladium-catalyzed carbonylative cyclization of benzyl chlorides with anthranils for the synthesis of 3-arylquinolin-2(1: H)-ones

An efficient carbonylative procedure for the synthesis of 3-arylquinoin-2(1H)-ones has been established. Through a palladium-catalyzed aminocarbonylation of benzyl chlorides with anthranils, a variety of 3-arylquinoin-2(1H)-one products were obtained in moderate to excellent yields with good functional group tolerance. This journal is

Palladium-catalyzed carbonylative synthesis of 3-arylquinolin-2(1H)-ones from benzyl chlorides and o-nitrobenzaldehydes

A palladium-catalyzed carbonylative cyclization of benzyl chlorides with o-nitrobenzaldehydes has been developed for the synthesis of 3-arylquinolin-2(1H)-ones. Mo(CO)6 played a dual role as both a CO surrogate and a reductant in this carbonylative transformation.

Preparation method of 3-aryl quinoline-2 (1H) ketone derivative

The invention discloses a preparation method of a 3-aryl quinoline-2 (1H) ketone derivative. The method comprises the following steps: carrying out a reaction on palladium acetate, S)-1, 1'-binaphthyl-2, 2'-diphenylphosphine, carbonyl molybdenum, triethylamine, water, benzisoxazole and a benzyl chloride compound at 100 DEG C for 26 hours, and after the reaction is completed, carrying out post-treatment to obtain the 3-aryl quinoline-2 (1H) ketone derivative. According to the preparation method, benzisoxazole is used as a nitrogen source and a formyl source, the operation is simple, the reaction initial raw materials are cheap and easy to obtain, the tolerance range of substrate functional groups is wide, and the reaction efficiency is high; and various 3-aryl quinoline-2 (1H) ketone derivatives can be synthesized according to actual needs, and the practicability of the method is widened while the operation is convenient.