3833-78-1

Basic information

• Product Name: 7-trifluoromethyl-quinazoline-2,4-diol
• CAS NO: 3833-78-1
• Molecular Weight: 230.146
• Mol File: 3833-78-1.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 7-trifluoromethyl-quinazoline-2,4-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 7-trifluoromethyl-quinazoline-2,4-diol(3833-78-1)
• EPA Substance Registry System: 7-trifluoromethyl-quinazoline-2,4-diol(3833-78-1)

Safety Data

• Hazardous Substances Data: 3833-78-1(Hazardous Substances Data)

Usage

General Description

7-trifluoromethyl-quinazoline-2,4-diol is a chemical compound with the molecular formula C9H6F3N3O2. It belongs to the quinazoline class of organic compounds and is characterized by the presence of a trifluoromethyl group and a dihydroxyquinazoline core. 7-trifluoromethyl-quinazoline-2,4-diol has potential applications in pharmaceutical research and drug development due to its unique structure and potential biological activities. It may have therapeutic properties or be used as a building block for the synthesis of new pharmaceuticals. Additionally, its trifluoromethyl group makes it useful in medicinal chemistry for enhancing the potency and pharmacokinetic properties of drug candidates. Overall, 7-trifluoromethyl-quinazoline-2,4-diol has the potential to contribute to the development of new and improved drugs for various medical conditions.

Upstream product

• 402-13-1 2-amino-4-trifluoromethylbenzoic acid 
• 57-13-6 urea 
• 917-61-3 sodium isocyanate 
• 89-77-0 2-Amino-4-chlorobenzoic acid 
• 320-94-5 2-nitro-4-trifluoromethylbenzoic acid 
• 778-94-9 2-nitro-4-trifluoromethyl-benzonitrile 

Downstream Products

• 396-02-1 2,4-dichloro-7-(trifluoromethyl)quinazoline 
• 159870-93-6 2-chloro-7-(trifluoromethyl)quinazolin-4(3H)-one 
• 1379685-86-5 2-[(1R,2R)-2-(dimethylamino)cyclohexylamino]-7-(trifluoromethyl)quinazolin-4(3H)-one 
• 1379685-87-6 2-[(1R,2R)-2-(diethylamino)cyclohexylamino]-7-(trifluoromethyl)quinazolin-4(3H)-one 
• 1379685-88-7 2-[(1R,2R)-2-(dipropylamino)cyclohexylamino]-7-(trifluoromethyl)quinazolin-4(3H)-one 
• 1379685-89-8 2-[(1R,2R)-2-(piperidin-1-yl)cyclohexylamino]-7-(trifluoromethyl)quinazolin-4(3H)-one 
• 1379685-90-1 2-[(1R,2R)-2-(isopropylamino)cyclohexylamino]-7-(trifluoromethyl)quinazolin-4(3H)-one 
• 1379685-93-4 2-[(1S,2S)-2-(dimethylamino)-1,2-diphenylethylamino]-7-(trifluoromethyl)quinazolin-4(3H)-one 
• 1379685-94-5 2-[(1S,2S)-2-amino-1,2-diphenylethylamino]-7-(trifluoromethyl)quinazolin-4(3H)-one 
• 1379686-21-1 CHF₃O₃S*C₁₇H₁₄F₃N₃O 
• 1388043-95-5 2-chloro-7-(trifluoromethyl)quinazoline 
• 1447640-41-6 2-((3,5-bis(trifluoromethyl)phenyl)amino)-7-(trifluoromethyl)quinazolin-4(3H)-one 
• 1278575-38-4 [2-(4-trifluoromethylphenyl)-7-trifluoromethyl-quinazolin-4-yl]ethylamine 

Relevant articles and documents

Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments

Despite the rising threat of fatal coronaviruses, there are no general proven effective antivirals to treat them. 2-Aminoquinazolin-4(3H)-one derivatives were newly designed, synthesized, and investigated to show the inhibitory effects on SARS-CoV-2 and MERS-CoV. Among the synthesized derivatives, 7-chloro-2-((3,5-dichlorophenyl)amino)quinazolin-4(3H)-one (9g) and 2-((3,5-dichlorophenyl)amino)-5-hydroxyquinazolin-4 (3H)-one (11e) showed the most potent anti-SARS-CoV-2 activities (IC50 50 50 > 25 μM). In addition, both compounds showed acceptable results in metabolic stabilities, hERG binding affinities, CYP inhibitions, and preliminary PK studies.

METHODS OF CULTURING AND/OR EXPANDING STEM CELLS AND/OR LINEAGE COMMITTED PROGENITOR CELLS USING AMIDO COMPOUNDS

Provided are methods for expanding stem cells and/or lineage committed progenitor cells, such as hematopoietic stems cells and/or lineage committed progenitor cells, at least in part, by using compounds that antagonize AhR. The compounds are represented by formulae (I) (II) (III) (IV), wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.

Facile and efficient synthesis of quinazoline-2,4(1H,3H)-diones through sequential hydrogenation condensation

The heterocyclizations from various methyl (2-nitrobenzoyl)carbamates to substituted quinazoline-2,4(1H,3H)-diones under hydrogenation conditions were investigated in this study. In the presence of p-toluenesulfonic acid monohydrate in methanol, various q