38594-42-2

Basic information

• Product Name: 2,3-DICHLOROBENZYL ALCOHOL
• Synonyms: RARECHEM AL BD 0205;2,3-DICHLOROBENZYL ALCOHOL;Dichlorobenzylalcohol;2,3-DICHLOROBENZYL ALCOHOL 99%;2,3-Dichlorobenzyl alcohol,99%;2,3-dichloroBenzenemethanol
• CAS NO: 38594-42-2
• Molecular Formula: C₇H₆Cl₂O
• Molecular Weight: 177.03
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;Alcohols;C7 to C8;Oxygen Compounds
• Mol File: 38594-42-2.mol
• Article Data: 16

Chemical Properties

• Melting Point: 85-88 °C(lit.)
• Boiling Point: 271.2 °C at 760 mmHg
• Flash Point: 115.8 °C
• Appearance: white crystalline powder
• Density: 1.392 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 13.69±0.10(Predicted)
• CAS DataBase Reference: 2,3-DICHLOROBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DICHLOROBENZYL ALCOHOL(38594-42-2)
• EPA Substance Registry System: 2,3-DICHLOROBENZYL ALCOHOL(38594-42-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 38594-42-2(Hazardous Substances Data)

Usage

Description

2,3-Dichlorobenzyl alcohol, also known as (2,3-dichlorophenyl)methanol (IUPAC name), is a white crystalline powder with mildly antiseptic properties. It is an organic compound that finds applications in the synthesis of various chemical compounds.

Uses

Used in Pharmaceutical Industry:
2,3-Dichlorobenzyl alcohol is used as a synthetic intermediate for the preparation of complex organic molecules, particularly in the pharmaceutical industry. Its antiseptic nature makes it a valuable component in the development of new drugs and medicinal compounds.
Specifically, it is used in the preparation of:
1. Methyl [2,3-dichlorobenzyl 4,7,8-tri-O-acetyl-9-azido-3,5,9-trideoxy-5-(2-nitrophenylsulfonamido)-D-glycero-α-D-galacto-2-nonulopyranosid]onate
2. Methyl [2,3-dichlorobenzyl 5-acetamido-4,7,8-tri-O-acetyl-3,5,9-trideoxy-9-(4-phenylbenzamido)-D-glycero-α-D-galacto-2-nonulopyranosid]onate
These complex molecules have potential applications in the development of new drugs and therapies, highlighting the importance of 2,3-dichlorobenzyl alcohol as a key component in the pharmaceutical industry.

Upstream product

• 6334-18-5 2,3-dichlorobenzylaldehyde 
• 32768-54-0 2,3-dichlorotoluene 
• 2905-54-6 2,3-Dichlorobenzoic acid methyl ester 
• 50-45-3 2,3-dichlorbenzoic acid 
• 608-27-5 2,3-dichloroaniline 
• 57915-78-3 1-(bromomethyl)-2,3-dichlorobenzene 

Downstream Products

• 442628-43-5 2,3-dichlorobenzyl methanesulphonate 
• 3218-45-9 2,3-dichlorophenylacetonitrile 
• 39959-98-3 ethyl 2-cyano-3-(2,3-dichlorophenyl)propanoate 
• 1420468-62-7 3-(2,3-dichlorobenzyl)-5-(pyridin-4-yl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-ol 
• 57915-78-3 1-(bromomethyl)-2,3-dichlorobenzene 
• 227754-33-8 O-(2,3-dichlorobenzyl)hydroxylamine 
• 321430-36-8 2-(2,3-Dichloro-benzyloxy)-isoindole-1,3-dione 
• 239132-51-5 5-(2,3-dichlorophenyl)-cyclohexane-1,3-dione 
• 3290-01-5 2,3-dichlorobenzyl chloride 
• 10236-60-9 (2,3-dichlorophenyl)acetic acid 

Relevant articles and documents

Synthetic process of 2,3-dichlorobenzaldehyde

The invention discloses a synthetic process of 2,3-dichlorobenzaldehyde. The synthetic process comprises the steps that 2,3-dichlorotoluene is used as a raw material, bromine is used as an auxiliary material, azodiisobutyronitrile is used as a catalyst, the bromine utilization rate is improved through hydrogen peroxide, the generated 2,3-dichlorobenzyl bromide is hydrolyzed into 2,3-dichlorobenzaldehyde in 30 wt% of sodium carbonate water solution, the 2,3-dichlorobenzaldehyde is generated by using hydrogen bromide to catalyze hydrogen peroxide oxidization, the total yield is 70% or above, and the product purity is 99.25% or above. The raw material conversion rate and selectivity of the process are high. In addition, the by-product production rate is reduced, the bromine utilization rate is improved, the bromine usage amount is decreased, and the synthetic process is greener and environmentally friendly compared with a traditional metal-catalyzed oxidation technology.

Selective Pinacol-Coupling Reaction using a Continuous Flow System

The first continuous flow pinacol coupling reaction of carbonyl compounds was successfully achieved within only 2 min during a single pass through a cartridge filled with zinc(0). The optimized method allowed the efficient production of gram-scale value-added compounds with high productivity. The developed methodology is efficient for aromatic or α,β-unsaturated aldehydes but gives moderate results for more stable acetophenone derivatives. Moreover, the flow method displayed better results in terms of yield and selectivity in comparison to the corresponding batch methodology.

Pyrazolopyrimidine derivatives as PI3 kinase inhibitors

PI3Kβ selective compounds having the structure