38652-23-2

Basic information

• Product Name: 1-cyclohexyl-3-(4-hydroxyphenyl)urea
• Synonyms: 1-cyclohexyl-3-(4-hydroxyphenyl)urea;N-Cyclohexyl-N'-(4-hydroxyphenyl)urea;N-Cyclohexyl-N'-(p-hydroxyphenyl)urea
• CAS NO: 38652-23-2
• Molecular Formula: C₁₃H₁₈N₂O₂
• Molecular Weight: 234
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 38652-23-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: DMSO, Methanol
• CAS DataBase Reference: 1-cyclohexyl-3-(4-hydroxyphenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-cyclohexyl-3-(4-hydroxyphenyl)urea(38652-23-2)
• EPA Substance Registry System: 1-cyclohexyl-3-(4-hydroxyphenyl)urea(38652-23-2)

Safety Data

• Hazardous Substances Data: 38652-23-2(Hazardous Substances Data)

Usage

Chemical Properties

Orange Solid

Upstream product

• 108-91-8 cyclohexylamine 
• 214360-73-3 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline 
• 123-30-8 4-amino-phenol 
• 3173-53-3 Cyclohexyl isocyanate 

Downstream Products

• 38651-95-5 1-Cyclohexyl-3-[4-(3-cyclohexylamino-2-hydroxy-propoxy)-phenyl]-urea 
• 38652-01-6 1-Cyclohexyl-3-{4-[2-hydroxy-3-(1,1,3,3-tetramethyl-butylamino)-propoxy]-phenyl}-urea 
• 38649-70-6 1-Cyclohexyl-3-[4-(2-hydroxy-3-isopropylamino-propoxy)-phenyl]-urea 
• 38649-72-8 1-Cyclohexyl-3-(4-oxiranylmethoxy-phenyl)-urea 
• 108-91-8 cyclohexylamine 
• 76196-14-0 1-Cyclohexyl-3-{4-[2-hydroxy-3-(1-methyl-hexylamino)-propoxy]-phenyl}-urea 
• 76210-80-5 1-Cyclohexyl-3-(4-{3-[2-(3,4-dimethoxy-phenyl)-ethylamino]-2-hydroxy-propoxy}-phenyl)-urea 
• 76210-64-5 1-{4-[3-(4-Benzyl-piperazin-1-yl)-2-hydroxy-propoxy]-phenyl}-3-cyclohexyl-urea 
• 76196-15-1 1-Cyclohexyl-3-[4-(2-hydroxy-3-propylamino-propoxy)-phenyl]-urea 
• 76210-66-7 1-Cyclohexyl-3-(4-{2-hydroxy-3-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-propoxy}-phenyl)-urea 
• 38652-02-7 1-Cyclohexyl-3-(4-{3-[((E)-hex-2-enyl)amino]-2-hydroxy-propoxy}-phenyl)-urea 
• 38651-98-8 1-(4-{3-[((E)-But-2-enyl)amino]-2-hydroxy-propoxy}-phenyl)-3-cyclohexyl-urea 
• 38652-00-5 1-[4-(3-Cycloheptylamino-2-hydroxy-propoxy)-phenyl]-3-cyclohexyl-urea 
• 38651-99-9 1-Cyclohexyl-3-[4-(3-cyclopentylamino-2-hydroxy-propoxy)-phenyl]-urea 

Relevant articles and documents

Synthesis and antitumor activity of novel pyridino[2,3-d]pyrimidine urea derivatives

A series of novel N-(3-((6-bromopyrido[2,3-d]pyrimidin-4-yl)oxy)phenyl)pyrrolidine-1-carboxamide and 1-(3-((6-bromopyrido[2,3-d]pyrimidin-4-yl)oxy)phenyl)-3-propylurea derivatives were synthesized. Their antitumor activities against human breast carcinoma cells (MCF-7) and human colon cancer cells (HCT-116) in vitro were evaluated, using sorafenib as a positive control drug. Anticancer bioassays indicated that several compounds exhibited appreciable anticancer activity against MCF-7 and HCT-116 cells. Particularly, compounds 9g and 8b demonstrated the most significant inhibitory effect against HCT-116 and MCF-7 cells, with inhibition ratios of 25.56% and 26.46%, respectively. Additionally, the synthesized pyridine[2,3-d]pyrimidine derivatives containing a urea group moieties exhibited antitumor activities against MCF-7 and HCT-116 cells in vitro.

Development of tyrosinase labile protecting groups for amines

(Chemical Equation Presented) The development of two novel protecting groups for amines is described. Thus, a range of amines have been converted to ureas, and the deprotection of these upon exposure to mushroom tyrosinase (E.C. 1.14.18.1) has been demonstrated.