392621-90-8

Basic information

• Product Name: Carbamic acid, [2-[4-(4-piperidinylamino)phenyl]ethyl]-, 1,1-dimethylethyl ester
• CAS NO: 392621-90-8
• Molecular Formula: C18H29N3O2
• Molecular Weight: 319.447
• Mol File: 392621-90-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-[4-(4-piperidinylamino)phenyl]ethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-[4-(4-piperidinylamino)phenyl]ethyl]-, 1,1-dimethylethyl ester(392621-90-8)
• EPA Substance Registry System: Carbamic acid, [2-[4-(4-piperidinylamino)phenyl]ethyl]-, 1,1-dimethylethyl ester(392621-90-8)

Safety Data

• Hazardous Substances Data: 392621-90-8(Hazardous Substances Data)

Upstream product

• 94838-59-2 tert-butyl 4-aminophenethylcarbamate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 13472-00-9 p-Aminophenethylamine 
• 392621-86-2 tert-Butyl 4-[(1-benzyl-4-piperidinyl)amino]phenethylcarbamate 

Downstream Products

• 392622-97-8 tert-Butyl 4-({1-[(methylamino)carbonyl]-4-piperidinyl}amino)-phenethylcarbamate 
• 1133470-36-6 4-Fluorobenzyl 4-[4-(2-aminoethyl)anilino]-1-piperidinecarboxylate formate 
• 392632-16-5 4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-N-[4-(3,4-dimethoxyphenyl)butyl]-1-piperidinecarboxamide 
• 392624-85-0 4-[4-(2-{[(2S)-3-(4-{[tert-butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-N-(2,4-dichlorobenzyl)-1-piperidinecarboxamide 
• 392637-95-5 4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxy-propyl]amino}ethyl)anilino]-N-(3-fluorophenethyl)-1-piperidinecarboxamide 
• 392635-67-5 4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-N-(3-methoxybenzyl)-1-piperidinecarboxamide 
• 392643-77-5 4-Fluorobenzyl 4-[4-(2-{[(2S)-3-(4-{[tert-butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-1-piperidinecarboxylate 
• 392623-93-7 4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-N-(2,2,2-trifluoroethyl)-1-piperidinecarboxamide 
• 392623-59-5 4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-N-isopropyl-1-piperidinecarboxamide 
• 392623-10-8 4-[4-(2-{[(2S)-3-(4-{[tert-Butyl(diphenyl)silyl]oxy}phenoxy)-2-hydroxypropyl]amino}ethyl)anilino]-N-methyl-1-piperidinecarboxamide 
• 392631-88-8 4-(4-{2-[2-Hydroxy-3-(4-hydroxy-phenoxy)-propylamino]-ethyl}-phenylamino)-piperidine-1-carboxylic acid [4-(3,4-dimethoxy-phenyl)-butyl]-amide 

Relevant articles and documents

4-Aminopiperidine ureas as potent selective agonists of the human β3-Adrenergic receptor

The preparation and structure-activity relationships (SARs) of potent agonists of the human β3-adrenergic receptor (AR) derived from a 4-aminopiperidine scaffold are described. Examples combine human β3-AR potency with selectivity over human β1-AR and/or human β2-AR agonism. Compound 29s was identified as a potent (EC50 = 1 nM) and selective (greater than 400-fold over β1- with no β2-AR agonism) full β3-AR agonist with in vivo activity in a transgenic mouse model of thermogenesis.