3953-14-8

Basic information

• Product Name: Phenol, 4-(2-aminoethyl)-2-iodo-
• CAS NO: 3953-14-8
• Molecular Formula: C8H10INO
• Molecular Weight: 263.078
• Mol File: 3953-14-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Phenol, 4-(2-aminoethyl)-2-iodo-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4-(2-aminoethyl)-2-iodo-(3953-14-8)
• EPA Substance Registry System: Phenol, 4-(2-aminoethyl)-2-iodo-(3953-14-8)

Safety Data

• Hazardous Substances Data: 3953-14-8(Hazardous Substances Data)

Upstream product

• 51-67-2 tyrosamine 
• 60-19-5 tyramine hydrochloride 

Downstream Products

• 910303-25-2 (2-{4-[3-(acridin-9-ylamino)-propoxy]-3-iodo-phenyl}-ethyl)-carbamic acid tert-butyl ester 
• 910303-21-8 (2-{4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-prpopoxy]-3-iodo-phenyl}-ethyl)-carbamic acid tert-butyl ester 
• 910303-23-0 {2-[4-(3-amino-propoxy)-3-iodo-phenyl]-ethyl}-carbamic acid tert-butyl ester 
• 788824-50-0 [2-(4-hydroxy-3-iodo-phenyl)-ethyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

IMAGING AGENTS WITH IMPROVED PHARMACOKINETIC PROFILES

The invention relates to compounds suitable for use in an imaging agent said imaging agent showing an improved pharmacokinetic profile.

INHIBITOR IMAGING AGENTS

The present invention discloses that imaging agents which comprise a specific type of matrix metalloproteinase inhibitors (MMPi's) of the sulphonamide hydroxamate class labelled with an imaging moiety, are useful diagnostic imaging agents for in vivo imag

Determination of serum biotinidase activity with biotinyl derivatives of iodotyramines as substrates

We synthesized biotinylated mono- and di-iodotyramine and their radioactive counterparts and used these substances as substrates to estimate serum biotinidase activity in a radioassay system. The K(m) values determined for mono- and di-iodobiotinyl derivatives were 15.8 and 25.9 μM, respectively, whereas, the maximum velocities of the enzymatic reaction were 27.0 and 8.7 nmol · min-1 · mL-1, respectively. Both substrates competed with biocytin for the same active site of the enzyme and the K(i) values were 7.30 and 9.56 μM for the mono- and di-iodinated substrate, respectively. Higher assay sensitivity was obtained using [125I]biotinyl- monoiodotyramine as substrate, and the values obtained were directly related with those determined with the well-established colorimetric method (r = 0.9377, n = 31). However, for routine use, the assay may be accomplished by diluting the radiotracer with biocytin instead of its 'cold' counterpart, because it is a commercially available reagent. The values obtained in this case were very well correlated with those determined by the colorimetric assay as well (r = 0.9289, n = 31).