432-87-1

Basic information

• Product Name: 4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE
• Synonyms: 4-(trifluoromethylsulfonyl)-1-nitrobenzene;trifluoromethylsulfonylnitrobenzene;4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE
• CAS NO: 432-87-1
• Molecular Formula: C₇H₄F₃NO₄S
• Molecular Weight: 255.17
• Mol File: 432-87-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE(432-87-1)
• EPA Substance Registry System: 4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE(432-87-1)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 432-87-1(Hazardous Substances Data)

Usage

General Description

4-(Trifluoromethylsulfonyl)nitrobenzene is a chemical compound with the molecular formula C7H4F3NO4S. It is a nitrobenzene derivative that contains a trifluoromethylsulfonyl group. 4-(TRIFLUOROMETHYLSULFONYL)NITROBENZENE is used as a building block in organic synthesis and as a reagent in the manufacture of pharmaceuticals and agrochemicals. It is a yellow solid at room temperature and is insoluble in water. 4-(Trifluoromethylsulfonyl)nitrobenzene is known to have potential toxicity and may cause irritation to the skin, eyes, and respiratory system if exposed to high concentrations. It should be handled with care and stored in a well-ventilated area.

Upstream product

• 1961266-44-3 2,8-difluoro-5-(trifluoromethyl)-5H-dibenzo[b,d]thiophen-5-ium trifluoromethanesulfonate 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 1146127-11-8 (4-nitrophenyl)(2,4,6-trimethylphenyl)iodonium trifluoromethanesulfonate 
• 2926-29-6 Langlois reagent 
• 100-01-6 4-nitro-aniline 
• 1310070-02-0 (4-methoxyphenyl)(4-nitrophenyl)iodonium p-toluenesulfonate 
• 905718-45-8 [(4-nitrophenyl)(phenyl)iodonium trifluoromethanesulfonate] 
• 713-66-6 4-nitrophenyl trichloromethylsulfide 
• 636-98-6 p-nitrobenzene iodide 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 456-56-4 phenyl trifluoromethylsulfide 
• 84796-68-9 C₇H₄F₃N₃O₄S 
• 403-66-7 p-nitrophenyl trifluoromethyl sulfide 

Downstream Products

• 360-01-0 1-iodo-4-((trifluoromethyl)sulfonyl)benzene 
• 325-83-7 Trifluormethyl-<2-amino-benzthiazol-(6)-yl>-sulfon 
• 312-20-9 1-bromo-4-(trifluoromethylsulfonyl)benzene 
• 677008-29-6 C₁₂⁽¹¹⁾CH₉NO₃ 
• 2143-88-6 4-nitro-4'-methyl-1,1'-biphenyl 
• 402-54-0 p-nitrobenzotrifluoride 
• 944-30-9 p-fluorophenyl trifluoromethyl sulfone 
• 432-84-8 4-Hydroxyphenyltrifluoromethylsulphone 
• 473-27-8 4-(trifluoromethanesulfonyl)aniline 

Relevant articles and documents

Practical and efficient synthesis of aryl trifluoromethyl sulfones from arylsulfonyl chlorides with Umemoto's reagent II

A practical and efficient method for the synthesis of aryl trifluoromethyl sulfones has been developed by a tandem reaction of arylsulfonyl chlorides with Umemoto's reagent II. The advantageous features of this method are simple operation, mild reaction conditions, wide scope of substrates, high yield of products, and easy scalability.

Copper-Promoted Trifluoromethanesulfonylation and Trifluoromethylation of Arenediazonium Tetrafluoroborates with NaSO2CF3

A tunable chemoselective trifluoromethanesulfonylation and trifluoromethylation of arenediazonium tetrafluoroborates with Langlois' reagent (NaSO2CF3) was developed. The Cu2O-catalyzed reaction in DMSO gave aryl trifluoromethanesulfones as the major products. On the other hand, the trifluoromethylated arenes were produced in the presence of oxidant tert-butyl hydroperoxide, CuBF4(MeCN)4, and 2,2′;6′,2 terpyridine (tpy). Both of these transformations proceed under mild conditions and tolerate functional groups.

Convenient one-pot procedure for converting aryl sulfides to nitroaryl sulfones

When treated with nitrogen dioxide and ozone in inert solvent at 0°C or below, aryl sulfides underwent smooth oxidative nitration to give nitroaryl sulfones in good yield. Using this methodology, a series of mono- and di-nitrated aryl sulfones were prepared from methyl phenyl sulfide and diphenyl sulfide and their physical data are presented.