433-06-7

Basic information

• Product Name: 2,2,2-TRIFLUOROETHYL P-TOLUENESULFONATE
• Synonyms: P-TOLUENESULFONIC ACID 2,2,2-TRIFLUOROETHYL ESTER;TRIFLUORETHYLTOSYLATE;TRIFLUOROETHANOL TOSYLATE;2,2,2-TRIFLUOROETHYL P-TOLUENESULF;2,2,2-trifluoroethyl ester;2,2,2-trifluoro-, p-toluenesulfonate;o-(p-tosyl)a,a,a,-trifluoroethanol;2,2,2-Trifluoroethyl 4-methylbenzenesulphonate, 2,2,2-Trifluoroethyl tosylate
• CAS NO: 433-06-7
• Molecular Formula: C₉H₉F₃O₃S
• Molecular Weight: 254.23
• EINECS: 207-085-5
• Product Categories: blocks;BuildingBlocks;FluoroCompounds;API intermediates;Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Synthetic Organic Chemistry;Organic Building Blocks;Sulfur Compounds;Tosylates
• Mol File: 433-06-7.mol
• Article Data: 50

Chemical Properties

• Melting Point: 36-38 °C(lit.)
• Boiling Point: 87-92 °C0.1 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: White crystalline solid
• Density: 1 g/cm3
• Vapor Pressure: 0.00418mmHg at 25°C
• Refractive Index: 1.521
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Chloroform (Sparingly), Methanol (Sparingly)
• Sensitive: Moisture Sensitive
• BRN: 2699394
• CAS DataBase Reference: 2,2,2-TRIFLUOROETHYL P-TOLUENESULFONATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-TRIFLUOROETHYL P-TOLUENESULFONATE(433-06-7)
• EPA Substance Registry System: 2,2,2-TRIFLUOROETHYL P-TOLUENESULFONATE(433-06-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• TSCA: T
• HazardClass: IRRITANT
• Hazardous Substances Data: 433-06-7(Hazardous Substances Data)

Usage

Description

2,2,2-Trifluoroethyl p-toluenesulfonate, also known as 2,2,2-Trifluoroethyl Tosylate, is a white crystalline solid that serves as a trifluoroethylation agent in the chemical industry. It is characterized by its unique chemical properties, which make it a valuable compound for various applications.

Uses

Used in Pharmaceutical Industry:
2,2,2-Trifluoroethyl p-toluenesulfonate is used as a trifluoroethylation agent for the preparation of 2,2,2-trifluoroethyl phenyl sulfone, a potential 2,2,2-trifluoroethyl pronucleophile. This application is significant in the synthesis of various pharmaceutical compounds, as the trifluoroethyl group can enhance the biological activity and pharmacokinetic properties of the resulting molecules.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2,2,2-Trifluoroethyl p-toluenesulfonate is utilized as a reagent to introduce the trifluoroethyl group into various organic compounds. This modification can improve the stability, reactivity, and overall performance of the synthesized products, making it a valuable tool for chemists in developing new materials and compounds.
Used in Material Science:
2,2,2-Trifluoroethyl p-toluenesulfonate can also be employed in the development of novel materials with enhanced properties. The introduction of the trifluoroethyl group can lead to materials with improved thermal stability, chemical resistance, and other desirable characteristics, making it a useful component in the advancement of material science.

InChI:InChI=1/C7H8FNO2S/c1-9-12(10,11)7-4-2-6(8)3-5-7/h2-5,9H,1H3

Upstream product

• 288-32-4 1H-imidazole 
• 75-89-8 2,2,2-trifluoroethanol 
• 25370-91-6 N-benzyl-N'-(4-toluenesulfonyloxy)diimide N-oxide 
• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 17721-45-8 1-tosylazepane 
• 4703-22-4 N-tosylpiperidine 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 98-59-9 p-toluenesulfonyl chloride 
• 166903-46-4 1-[hydroxy(tosyloxy)iodo]-1H,1H-perfluoroethane 
• 371-67-5 2,2,2-trifluorodiazoethane 
• 104-15-4 toluene-4-sulfonic acid 

Downstream Products

• 143264-65-7 (1-Difluoromethylene-2-methyl-butyl)-benzene 
• 62158-91-2 (2,2,2-trifluoroethyl) (4-fluorophenyl) sulfide 
• 73194-23-7 2,2,2-trifluoroethyl phenyl selenide 
• 139680-97-0 2-butyl-3,3-difluoro-1-phenyl-prop-2-en-1-one 
• 139680-98-1 2-Difluoromethylene-1-(4-methoxy-phenyl)-hexan-1-one 
• 129264-94-4 (2,2,2-trifluoroethyl) (4-chlorophenyl) sulfide 
• 157060-87-2 5-(2,2,2-trifluoroethoxy)-1H-indole-3-carboxylic acid 
• 156091-18-8 1-Methyl-4-(2,2,2-trifluoro-ethylselanyl)-benzene 
• 93523-64-9 2,2-difluoro-1-tosyloxyvinyllithium 
• 62149-35-3 1-(2,2,2-trifluoroethoxy)-4-nitrobenzene 
• 324741-27-7 1-(t-Butoxycarbonyl)-4-[2-methoxy-5-(2,2,2-trifluoroethoxy)-phenyl]piperazine 
• 334929-98-5 5-Fluoro-2-(2,2,2-trifluoroethoxy)-nitrobenzene 
• 57946-60-8 2-(2',2',2'-trifluoroethoxy)aniline 
• 76579-46-9 4-(2,2,2-trifluoroethoxy)benzaldehyde 

Relevant articles and documents

Synthesis of new fluorinated imidazolium ionic liquids and their prospective function as the electrolytes for lithium-ion batteries

Two fluorine-containing ionic liquids, 1-(2,2,2-trifluoroethyl)-3- methylimidazolium tosylate and 1-(2,2,2-trifluoroethyl)-3-methylimidazolium bis(trifluoromethanesulfonyl)imide (TFSI anion), were obtained in good yields and high purity via a green pathway procedure free of solvent and hazardous catalyst. The incorporation of CF3 moieties in imidazolium structure decreases the ILs TFSI melting point. The preliminary electrochemical results are very promising, a wide electrochemical stability up to 5.7 V vs Li +/Li for the fluorinated imidazolium with TFSI anion.

KIF18A INHIBITORS

Compounds of formula (I): as defined herein, and synthetic intermediates thereof, which are capable of modulating KIF18A protein thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of KIF18A.

Palladium-Catalyzed Fluoroarylation of gem-Difluoroenynes to Access Trisubstituted Trifluoromethyl Allenes

Various new transformations of gem-difluoroalkenes leading to trifluoromethyl substituted compounds have been well established in the past years. However, the development of new transformations of gem-difluoroenynes lags much behind. Herein is reported the fluoroarylation of 1,1-difluoro-1,3-enynes with aryl halides in the presence of silver fluoride affording trisubstituted trifluoromethyl allenes under the catalysis of palladium. The reaction features mild conditions, high functional-group tolerance, and high regioselectivity.