4703-22-4

Basic information

• Product Name: 1-[(4-methylphenyl)sulfonyl]piperidine
• Synonyms: 1-[(4-methylphenyl)sulfonyl]piperidine;1-(p-Tolylsulfonyl)piperidine;4-Methylphenylpiperidino sulfone;Piperidino(4-methylphenyl) sulfone
• CAS NO: 4703-22-4
• Molecular Formula: C₁₂H₁₇NO₂S
• Molecular Weight: 239.33
• Mol File: 4703-22-4.mol
• Article Data: 101

Chemical Properties

• Boiling Point: 368.2°C at 760 mmHg
• Flash Point: 176.5°C
• Appearance: /
• Density: 1.19g/cm³
• Vapor Pressure: 1.29E-05mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: 1-[(4-methylphenyl)sulfonyl]piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4-methylphenyl)sulfonyl]piperidine(4703-22-4)
• EPA Substance Registry System: 1-[(4-methylphenyl)sulfonyl]piperidine(4703-22-4)

Safety Data

• Hazardous Substances Data: 4703-22-4(Hazardous Substances Data)

Usage

Chemical structure

Contains a piperidine ring with a sulfonyl group attached to a 4-methylphenyl moiety.

Usage

Commonly used as a precursor in the synthesis of various pharmaceuticals and agrochemicals.

Polar properties

The sulfonyl group imparts polar properties to the compound.

Acidic properties

The sulfonyl group also imparts acidic properties to the compound.

Basic properties

The presence of the piperidine ring confers basic properties to the compound.

Versatility

Useful in organic synthesis reactions and as a building block in the production of drugs and other bioactive compounds.

Applications

Finds applications in the pharmaceutical, chemical, and agricultural industries.

InChI:InChI=1/C12H17NO2S/c1-11-5-7-12(8-6-11)16(14,15)13-9-3-2-4-10-13/h5-8H,2-4,9-10H2,1H3

Upstream product

• 111-24-0 1,5-dibromo-pentane 
• 29281-83-2 4-methylbenzensulphonamide potassium salt 
• 536-57-2 p-toluene sulfinic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 195874-54-5 C₁₉H₂₀N₂O₂Se 
• 110-89-4 piperidine 
• 34147-85-8 p-(Toluolsulfonyloxy)-azobenzol 
• 742-25-6 2,4-dinitrophenyl 4-methylbenzenesulfonate 
• 599-89-3 4-chlorophenyl p-toluenesulfonate 
• 1153-45-3 4-nitrophenyl 4-methylbenzenesulfonate 
• 6286-84-6 2,4-dibromophenyl 4-methylbenzenesulfonate 
• 88791-50-8 toluene-4-sulfonic acid 2,6-dinitro-phenyl ester 
• 88791-51-9 Toluene-4-sulfonic acid 2,5-dinitro-phenyl ester 
• 7466-04-8 2,4,6-trichlorophenyltosylate 

Downstream Products

• 433-06-7 2,2,2-Trifluoroethyl p-toluenesulfonate 
• 63587-57-5 2-methyl-1-(toluene-4-sulfonyl)-piperidine 
• 1201516-76-8 2-(octan-2-yl)-1-tosylpiperidine 
• 6091-44-7 piperidine hydrochloride 
• 91411-09-5 1-<(4-Methylphenyl)sulfonyl>-2,6-dimethoxypiperidine 
• 134415-28-4 1-<(4-Methylphenyl)sulfonyl>-2-methoxypiperidine 
• 1950-78-3 p-toluenesulfonyl iodide 
• 3333-08-2 N,N-dimethylpiperidinium iodide 

Relevant articles and documents

Direct Hydrodecarboxylation of Aliphatic Carboxylic Acids: Metal- and Light-Free

A mild and inexpensive method for direct hydrodecarboxylation of aliphatic carboxylic acids has been developed. The reaction does not require metals, light, or catalysts, rendering the protocol operationally simple, easy to scale, and more sustainable. Crucially, no additional H atom source is required in most cases, while a broad substrate scope and functional group tolerance are observed.

Synthesis method of aryl tertiary sulfonamide compounds promoted by visible light

The invention provides a synthesis method of aryl tertiary sulfonamide compounds promoted by visible light. In a non-protonic solvent, N-benzyl tertiary amine and arylsulfonyl chloride are used as rawmaterials, under the conditions of photosensitizer catalysis and illumination, a reaction is carried out for 1-4h at room temperature, and then separation and purification are carried out to obtain the product. The synthesis method of the aryl tertiary sulfonamide compound provided by the invention has the advantages of mild reaction conditions, simplicity and convenience in operation, short reaction time, no need of any transition metal catalysis and environmental friendliness.

A General Organocatalytic System for Electron Donor-Acceptor Complex Photoactivation and Its Use in Radical Processes

We report herein a modular class of organic catalysts that, acting as donors, can readily form photoactive electron donor-acceptor (EDA) complexes with a variety of radical precursors. Excitation with visible light generates open-shell intermediates under mild conditions, including nonstabilized carbon radicals and nitrogen-centered radicals. The modular nature of the commercially available xanthogenate and dithiocarbamate anion organocatalysts offers a versatile EDA complex catalytic platform for developing mechanistically distinct radical reactions, encompassing redox-neutral and net-reductive processes. Mechanistic investigations, by means of quantum yield determination, established that a closed catalytic cycle is operational for all of the developed radical processes, highlighting the ability of the organic catalysts to turn over and iteratively drive every catalytic cycle. We also demonstrate how the catalysts' stability and the method's high functional group tolerance could be advantageous for the direct radical functionalization of abundant functional groups, including aliphatic carboxylic acids and amines, and for applications in the late-stage elaboration of biorelevant compounds and enantioselective radical catalysis.