4330-21-6 Usage
Description
2-Deoxy-alpha-D-erythropentofuranosyl chloride 3,5-bis(4-methylbenzoate) is a synthetic compound with a unique chemical structure, characterized by its white solid appearance. It is a chlorosugar derivative, specifically designed as a synthetic precursor for the production of ribose glycosides and ribonucleosides, which are essential components in various biological processes.
Uses
Used in Pharmaceutical Industry:
2-Deoxy-alpha-D-erythropentofuranosyl chloride 3,5-bis(4-methylbenzoate) is used as a synthetic precursor for the development of ribose glycosides and ribonucleosides. These compounds play a crucial role in the synthesis of nucleic acids, which are the building blocks of genetic material in living organisms. The application of this chlorosugar derivative in the pharmaceutical industry is primarily due to its ability to facilitate the production of essential biomolecules, thereby contributing to the advancement of drug discovery and development.
Used in Chemical Research:
In the field of chemical research, 2-Deoxy-alpha-D-erythropentofuranosyl chloride 3,5-bis(4-methylbenzoate) serves as an important intermediate for the synthesis of various complex organic molecules. Its unique structure allows chemists to explore new reaction pathways and develop innovative synthetic strategies, leading to the creation of novel compounds with potential applications in various industries, including pharmaceuticals, materials science, and agrochemicals.
Used in Biochemical Studies:
2-Deoxy-alpha-D-erythropentofuranosyl chloride 3,5-bis(4-methylbenzoate) is also utilized in biochemical studies to investigate the role of ribose glycosides and ribonucleosides in cellular processes. By using this chlorosugar derivative as a starting material, researchers can gain insights into the mechanisms of nucleic acid synthesis, enzyme catalysis, and other biological reactions involving these essential biomolecules. This knowledge can be applied to develop targeted therapies for various diseases and improve our understanding of fundamental biological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 4330-21-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,3 and 0 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 4330-21:
(6*4)+(5*3)+(4*3)+(3*0)+(2*2)+(1*1)=56
56 % 10 = 6
So 4330-21-6 is a valid CAS Registry Number.
InChI:InChI=1/C21H21ClO5/c1-13-3-7-15(8-4-13)20(23)25-12-18-17(11-19(22)26-18)27-21(24)16-9-5-14(2)6-10-16/h3-10,17-19H,11-12H2,1-2H3
4330-21-6Relevant articles and documents
Benzimidazole derivative BI292 as well as preparation method and application thereof
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Paragraph 0019; 0021-0024, (2021/06/09)
The invention discloses a benzimidazole derivative BI292 and a preparation method thereof, and the benzimidazole derivative BI292 is chemically named as 1-[(2R, 4S, 5R)-4-hydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl]-1H-benzo [d] imidazole-4-carboxylic acid methyl ester. The benzimidazole derivative and the pharmaceutically acceptable salt, the solvate and the hydrate of the benzimidazole derivative have excellent in-vivo and in-vitro anti-tumor activity on MCF-7, SK-BR-3, HCT 116, U-118 MG, U-87 MG and MDA-MB-468, and have a relatively good application prospect in preparation of anti-tumor drugs.
SOLID STATE FORMS OF 5-CHLORO-6-[(2-IMINOPYRROLIDIN-1-YL)METHYL]PYRIMIDINE-2,4-(1H,3H)-DIONE HYDROCHLORIDE AND THEIR PROCESSES FOR THE PREPARATION THEREOF
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Page/Page column 40, (2019/04/09)
The present invention relates to solid state forms of 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione hydrochloride compound of formula-1a and their processes for the preparation thereof and an improved process for the preparation of 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione hydrochloride. The present inventors also provides an amorphous polymorph of the combination drug consisting of 2'-deoxy-5-(trifluoromethyl) uridine and 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione monohydrochloride and its process for the preparation.
Preparation of pyridine-stretched 2′-deoxyhypoxanthosine phosphoramidite
Clayton, Russell,Davis, Michael L.,Li, Wei,Fraser, William,Ramsden, Christopher A.
, p. 87 - 104 (2017/06/19)
Pyridine-stretched 2-deoxyhypoxanthosine (strH) phosphoramidite was prepared in eight steps from Hoffer's sugar (2-deoxy-3,5-di-O-(p-toluoyl)-a-D-erythro-pentofuranosyl chloride). Improved synthesis of the Hoffer sugar was achieved without need for distillation or chromatographic separation of intermediates, or use of gaseous HCl. Conditions were optimised to provide a key nitrile intermediate for the preparation of strH whereby the cesium salt of 4(5)-nitroimidazole was glycosylated using Hoffer's sugar. The nitrile intermediate was also used to prepare pyridine-stretched 2-deoxyadenosine (strA) and pyridine-stretched 2-deoxy-2,6-diaminonebulamine (strD). Preliminary studies indicate that strH forms a stronger, size-expanded base pair with adenine compared with the Watson-Crick thymine-adenine base pair.