4469-03-8

Basic information

• Product Name: 3α-hydroxy-5β-pregnan-20-one
• Synonyms: 3α-hydroxy-5β-pregnan-20-one
• CAS NO: 4469-03-8
• Molecular Weight: 318.5
• Mol File: 4469-03-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3α-hydroxy-5β-pregnan-20-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3α-hydroxy-5β-pregnan-20-one(4469-03-8)
• EPA Substance Registry System: 3α-hydroxy-5β-pregnan-20-one(4469-03-8)

Safety Data

• Hazardous Substances Data: 4469-03-8(Hazardous Substances Data)

Upstream product

• 75517-77-0 (1S,4aS,4bS,7S,8aS,10aR)-2,4b-Dimethyl-1-pent-3-ynyl-tetradecahydro-phenanthrene-2,7-diol 
• 64-19-7 acetic acid 
• 1852-49-9 pregnanediol-3α-glucuronide 
• 128-23-4 pregnanedione 
• 110-54-3 hexane 
• 57-83-0 Progesterone 

Downstream Products

• 2497-72-5 3α-hydroxy-5β-pregnan-20-one-(2,4-dinitro-phenylhydrazone) 
• 96737-93-8 5β-pregnan-3α-ol-20-one, 17,21,21,21-d4 
• 20810-60-0 C₂₈H₄₂N₂O₃S 
• 80-92-2 pregnanediol 
• 1393644-97-7 20-oxo-5β-pregnan-3α-yl (2S)-2-(benzyloxycarbonylamino)-5-(3-nitroguanidino)pentanoate 
• 1256911-16-6 20-Oxo-5β-pregnan-3α-yl (2S)-4-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-4-oxobutanoate 
• 1256911-22-4 20-oxo-5β-pregnan-3α-yl (2S)-5-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-5-oxo-pentanoate 
• 124107-39-7 pregnanolone sulfate pyridinium salt 
• 906-83-2 Pregnanolon-3β-acetat 
• 2402-24-6 21-acetoxy-3α-hydroxy-5β-pregnan-20-one 
• 2402-25-7 21-acetoxy-5β-pregnane-3,20-dione 
• 566-60-9 3α-hydroxy-5β-pregn-16-en-20-one 
• 80-89-7 pregnadiol 

Relevant articles and documents

METHODS OF NEUROPROTECTION USING NEUROPROTECTIVE STEROIDS AND A VITAMIN D

Described herein are compositions and methods for treating or preventing nervous system injury. In particular, the methods and compositions relate to the use of at least one neuroprotective steroid, such as progesterone, and vitamin D.

METABOLISM AND CONJUGATION OF PROGESTERONE BY BOVINE LIVER AND ADIPOSE TISSUES, IN VITRO

The ability of bovine liver and fat to metabolize progesterone and also to form glucuronide conjugates with these progestins in vitro was investigated.Tissue supernatants were incubated with progesterone, UDP-glucuronic acid, and a NADPH generating system for 5 hr, at 37 deg C.Steroids were identified by thin-layer chromatography, high performance liquid chromatography, and recrystallization to a constant specific activity.The total original radioactivity which could not be removed by exhaustive ether extraction (presumptive conjugates) was 44.7 +/- 14.2percent in liver, 5.0 +/- 3.6percent in subcutaneous fat, and 3.7 +/- 2.2percent in kidney fat samples.Progestins identified in liver samples include 5β-pregnane-3α,20α-diol (free and conjugate), 5β-pregnane-3α,20β-diol (free and conjugate), 3α-hydroxy-5β-pregnan-20-one (free and conjugate), 3β-hydroxy-5β-pregnan-20-one (free), 5β-pregnane-3,20-dione (free), and progesterone (conjugate).Progestins identified in both the free and conjugate fractions of subcutaneous fat and kidney fat samples include progesterone, 3α-hydroxy-5β-pregnan-20-one, 20β-hydroxy-4-pregnen-3-one, and 20α-hydroxy-4-pregnen-3-one.Differences due to sex of bovine used were noted.These results confirm the ability of bovine liver to readily metabolize progesterone and form glucuronide conjugates of these compounds and suggest that adipose tissues take an active role in these actions in cattle.