453-35-0 Usage
Description
1,1,1-Trifluoro-3-nitropropan-2-ol, with the chemical formula CF3CH(OH)CH(NO2)CH3, is a colorless liquid characterized by a strong odor. This chemical compound serves as a versatile intermediate in the synthesis of various products, including pharmaceuticals, agricultural chemicals, and other organic compounds. Additionally, it functions as a solvent in a range of chemical reactions. Due to its toxic nature, it is crucial to handle 1,1,1-trifluoro-3-nitropropan-2-ol with care, adhering to safety protocols such as wearing protective gear and working in well-ventilated environments.
Uses
Used in Pharmaceutical Synthesis:
1,1,1-Trifluoro-3-nitropropan-2-ol is utilized as a key intermediate in the production of pharmaceuticals, contributing to the development of new medications and therapeutic agents. Its unique chemical structure allows it to participate in various chemical reactions, facilitating the synthesis of a wide array of drug compounds.
Used in Agricultural Chemical Production:
1,1,1-TRIFLUORO-3-NITROPROPAN-2-OL also plays a significant role in the synthesis of agricultural chemicals, such as pesticides and herbicides. Its application in this industry aids in the development of more effective and targeted agrochemicals to enhance crop protection and yield.
Used as a Solvent in Chemical Reactions:
1,1,1-Trifluoro-3-nitropropan-2-ol is employed as a solvent in numerous chemical processes, providing a medium for reactions to occur. Its properties enable it to dissolve a variety of substances and facilitate the progress of chemical reactions, making it a valuable component in the synthesis of numerous organic compounds.
Used in Organic Compound Synthesis:
Beyond its applications in pharmaceuticals and agricultural chemicals, 1,1,1-trifluoro-3-nitropropan-2-ol is also used in the synthesis of other organic compounds. Its versatility as a chemical intermediate allows it to be incorporated into the production of a diverse range of organic substances, expanding its utility across various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 453-35-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,5 and 3 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 453-35:
(5*4)+(4*5)+(3*3)+(2*3)+(1*5)=60
60 % 10 = 0
So 453-35-0 is a valid CAS Registry Number.
InChI:InChI=1/C3H4F3NO3/c4-3(5,6)2(8)1-7(9)10/h2,8H,1H2
453-35-0Relevant articles and documents
Highly regio- and stereoselective 1,3-dipolar cycloaddition of stabilised azomethine ylides to 3,3,3-trihalogeno-1-nitropropenes: Synthesis of trihalomethylated spiroindenepyrroli(zi)dines
Barkov, Alexey Yu.,Zimnitskiy, Nikolay S.,Kutyashev, Igor B.,Korotaev, Vladislav Yu.,Moshkin, Vladimir S.,Sosnovskikh, Vyacheslav Ya.
, p. 37 - 44 (2017)
Reactions of (E)-3,3,3-trihalogeno-1-nitropropenes with stabilised azomethine ylides derived from ninhydrin and indenoquinoxalinones on the one hand, and sarcosine and proline on the other, proceed regio- and diastereoselectively to give a number of trihalomethylated spiroindenepyrrolidines and spiroindenepyrrolizidines in good yields.
6,7-DIHYDRO-4H-PYRAZOLO[1,5-A]PYRAZINE COMPOUNDS FOR THE TREATMENT OF INFECTIOUS DISEASES
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Page/Page column 44-45, (2018/03/26)
The present invention relates to compounds of the formula (I) or pharmaceutically acceptable salts, enantiomer or diastereomer thereof, wherein R1 to R4 are as described above. The compounds may be useful for the treatment or prophylaxis of hepatitis B virus infection.
The asymmetric Friedel-Crafts reaction of indoles with fluoroalkylated nitroalkenes catalyzed by chiral phosphoric acid
Lin, Jin-Hong,Xiao, Ji-Chang
supporting information; experimental part, p. 4536 - 4539 (2011/10/09)
The enantioselective Friedel-Crafts fluoroalkylation of indoles with fluoroalkylated nitroalkenes, catalyzed by chiral phosphoric acid is described. The regioselectivity of fluoroalkylated nitroalkenes is a problem worth discussing, and it was found that the carbon atom adjacent to the fluoroalkyl group is more reactive than that adjacent to NO2 group.
