460346-07-0Relevant articles and documents
Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 2: Optimization of 5,8-disubstituted derivatives
Bernardelli, Patrick,Lorthiois, Edwige,Vergne, Fabrice,Oliveira, Chrystelle,Mafroud, Abdel-Kader,Proust, Emmanuelle,Pham, Nga,Ducrot, Pierre,Moreau, Fran?ois,Idrissi, Moulay,Tertre, Anita,Bertin, Bernadette,Coupe, Magali,Chevalier, Eric,Descours, Arnaud,Berlioz-Seux, Fran?oise,Berna, Patrick,Li, Mei
, p. 4627 - 4631 (2007/10/03)
The optimization of 5,8-disubstituted spirocyclohexane-quinazolinones into potent, selective, soluble PDE7 inhibitors with acceptable in vivo pharmacokinetic parameters is presented.